Research Advances on the Therapy of Rheumatoid Arthritis with the Nanotechnology Based on Transdermal Drug Delivery System

doi:10.13523/j.cb.2011013

China Biotechnology

2021, Vol. 41

Issue (2/3): 98-106 DOI: 10.13523/j.cb.2011013

Research Advances on the Therapy of Rheumatoid Arthritis with the Nanotechnology Based on Transdermal Drug Delivery System

HU Sheng-tao¹,ZHANG Er-bing¹,LIN Ye¹,ZHANG Feng¹,HUANG Dan¹,SONG Hou-pan¹,LIU Bin²,CAI Xiong^1,^**(

)

1 Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
2 College of Biology, Hunan University, Changsha 410082, China

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Abstract

Rheumatoid arthritis (RA) is a systemic, chronic autoimmune disease that is considered to be incurable. Less effective concentration of conventional drugs in the affected joints and more frequent adverse effects of even novel biological agents remain to be therapeutic challengs for RA. Advances in nanobiotechnology have facilitated the development of new classes of therapeutics with a focus on new drug delivery systems. Recent studies have shown that nanocarriers can significantly improve bioavailability of existing, traditional disease-modifying antirheumatic drugs (DMARS), and transdermal delivery can remarkably decrease toxic effects and adverse reaction of oral administration and injection of drugs. Here, nanomaterials used in the transdermal drug delivery system for RA therapy and target therapeutic strategies in the basic-research aspect of RA as well as the progress and existing issues of current nano-preparations are summarized so as to provide perspectives for further avenues of development and improved method of novel transdermal nanomaterial-loaded drug delivery systems.

Key words： Rheumatoid arthritis Nanocarrier Transdermal drug delivery Target therapy

Received: 05 November 2020 Published: 08 April 2021

ZTFLH:

Q819

Corresponding Authors: Xiong CAI E-mail: caixiong@hnucm.edu.cn

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	Sheng-tao HU
	Er-bing ZHANG
	Ye LIN
	Feng ZHANG
	Dan HUANG
	Hou-pan SONG
	Bin LIU
	Xiong CAI

Cite this article:

HU Sheng-tao,ZHANG Er-bing,LIN Ye,ZHANG Feng,HUANG Dan,SONG Hou-pan,LIU Bin,CAI Xiong. Research Advances on the Therapy of Rheumatoid Arthritis with the Nanotechnology Based on Transdermal Drug Delivery System. China Biotechnology, 2021, 41(2/3): 98-106.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2011013 OR https://manu60.magtech.com.cn/biotech/Y2021/V41/I2/3/98

Fig.1 Schematic diagram of nanocarrier (a)Nanoparticles (b)Solid lipid nanoparticles (c)Nanoemulsion (d)Liposomes (e)Nanogel

Fig.2 RA diseased joints and internal environment of pannus (a) Schematic diagram of RA diseased joints (b) Pannus environment

Fig.3 ELVIS effect mechanism diagram (a)Normal and (b)Inflammatory synovial tissue internal environment

Fig.4 Adhesion between leukocytes and endothelial cells (a)α_vβ₃ is highly expressed on endothelial cells (b)Cell-adhesion molecules are involved in the adhesion of leukocytes to endothelial cells Before leukocytes can migrate into surrounding tissue they roll on edothelial cells and subsequently arrest to the cell surface. The initial capture and rolling of leukocytes is mediated by the interaction of selectin molecules present on both leukocytes (L-selectin) and endothelial cells (P-selectin and E-selectin) with carbohydrate ligands on the reciprocal cell-surface membrane. Also, interactions between leukocyte integrins and vascular cell adhesion molecule 1 (VCAM-1) and intracellular adhesion molecules-1(ICAM-1) on the endothelium can mediate rolling of leukocytes. Leukocyte integrin molecules are activated by chemoattractants on the endothelial surface leading to mediate the migration of leukocytes and recruit in inflammatory tissues


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