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| Current Progress on the Signal Transduction Pathway of Innate Immunity in Caenorhabditis Elegans |
| WANG Tao1,2, DU Li1, MA Qiong1, CUI Yu-fang1 |
1. Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China;
2. State Key Laboratory of Millimeter Wave, Southeast University, Nanjing 210096, China |
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Abstract Caenorhabditis elegans(C. elegans) has been widely used as a model organism in the research of nervous system, aging mechanisms and programmed cell death, owing to its advantages of simple tissue structure, easily culture, short lifecycle. Different from higher organisms, C. elegans is lack of adaptive immune, only the innate immune plays an important role in anti-bacteria, anti-oxidative stress and so on. Four immune-related signal transduction pathway in C. elegans, including insulin-receptor-like pathway, transforming growth factor β(TGF-β) pathway, mitogen activated protein kinases(MAPK) pathway and programmed cell death(PCD) pathway play major roles in various conditions of environment. Meanwhile, the innate immune system of C. elegans is conservative in many respects, which provides new idea for research of immune mechanism in higher organisms. Accordingly.The progress on innate immune signal transduction pathway in C. elegans is reviewed, expecting to provide some reference for investigating innate immune related to higher organisms including mankinds.
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Received: 04 March 2011
Published: 25 July 2011
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