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| Biofabrication of Vital Parenchymal Organs |
| HE Jian-kang, LIU Ya-xiong, LIAN Qin, WANG Ling, JIN Zhong-min, LI Di-chen |
| State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710049, China |
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Abstract It is a dream of human being to restore the biologicial functions of damaged tissues or organs by using in vitro engineered living substitutes. The development and integration of manufacutring, material and life sciences have provided necessary technical, material and biological foundations for the biofabrication of artificial tissues and organs. Several artificial tissues with relatively simple structures (e.g., skin, bone and bladder) were already commercially available or in clinical trials. However, it is still challenging to regenerate vital parenchymal organs like liver and lung. One of the crucial issues is to recapitulate the native complex microstructural and multicellular organizations in artificial analogs. From the perspective of biomanufacutring, the major techniques and latest progress related to the regeneration of vital parenchymal organs were reviewed, analyzed and discussed. The future trend for the biofabrication of vital parenchymal organs was summarized.
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Received: 13 June 2012
Published: 25 September 2012
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