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| Research Progress in Neuronal Differentiation of Induced Pluripotent Stem Cell |
| SHAN Wei1, YU Qin1, LIU Li-zhen2, WANG Biao1 |
1. Institute of Biological Engineering, Zhejiang Chinese Medicine University, Hangzhou 310053, China;
2. Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China |
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Abstract Induced pluripotent stem cell (iPSC), which is generated by reprogramming the somatic cells through thansfection of a combination of specific genes, owns the similar biological properties with embryonic stem cell. iPSC is morphologically identical to embryonic stem cell and show infinite proliferation, self-renewal abilities, teratoma formation after subcutaneous injection and contribution to chimeric animals on injection into blastocysts. Several molecular and functional assays are set to evaluate the similarity of iPSC with embryonic stem cell. Furthermore, the generation of iPSC overcomes the ethical difficulties and the risk of transplant rejection by the host immune system, implying great clinical potential. Great progresses have been achieved in the area of iPSC about treating the diseases of central nervous system, including the improvement of the methods about neuronal differentiation, the research of differentiation mechanisms and the treatment of neuronal cells derived from iPSC on the diseases of nervous system. The creation and characteristic of iPSC and the methods about neuronal differentiation of iPSC are reviewed. It also summarizes the recent progress in neuronal differentiation of iPSC.
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Received: 12 January 2012
Published: 25 September 2012
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