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| Application of Hepatocyte-like Cells Derived from Induced Pluripotent Stem Cells in HCV Infection Model |
QIU Dan-dan1,2,LU Cai-xia2**( ),DAI Jie-jie2**() |
1 Kunming Medical University,Kunming 650504, China
2 Institute of Medical Biology, Chinese Academy of Medicine Sciences(CAMS)/Peking UnionMedical College(PUMC), Kunming 650118, China |
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Abstract Induced pluripotent stem cells (iPSCs) as well as embryonic stem cells(ESCs),is a kind of cells with potential of self-renewing and unlimited proliferation,has the potentian of inducing differentiation into all types of cells in every germ layer of the body. iPSCs are derived from the body itself, which avoids the immune rejection and medical ethics problems of ESCs and they play an important role in biomedical research. At present, iPS-derived hepatocyte-like cells(iHLCs) have been widely used in the establishment of in vitro and in vivo infection model of HCV.The HCV model based on iHLCs can be used to study the pathogenesis of HCV,the role of host genes in the pathogenesis of HCV, to screen new anti-HCV drugs and development of vaccine.The origin of iPSCs, the research methods of inducing iPSCs into functional liver cells by different strategies, and the application of iPSCs in HCV infection model were summarized.
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Received: 04 June 2020
Published: 11 December 2020
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Corresponding Authors:
Cai-xia LU,Jie-jie DAI
E-mail: lcx@imbcams.com.cn;djj@imbcams.com.cn
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