Research Progress of Chitosan Based Thermosensitive Hydrogels

doi:10.13523/j.cb.20180511

China Biotechnology

2018, Vol. 38

Issue (5): 79-84 DOI: 10.13523/j.cb.20180511

Research Progress of Chitosan Based Thermosensitive Hydrogels

Xi KANG,Ai-peng DENG,Shu-lin YANG(

)

School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

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Abstract

Chitosan is a biocompatible, low-toxic and biodegradable amino polysaccharide obtained by deacetylation of chitin. The classic gelling system of chitosan/β-sodium glycerophosphate thermosensitive hydrogel has been widely reported in tissue engineering, drug controlled release and other fields. The gels properties depend on the composition and concentration of solutions. To improve the defects of weak mechanical property, rapid degradation and drug burst release, researchers modified chitosan or blended it with other materials, expecting to get better thermosensitive hydrogels based on chitosan. The recent advances in chitosan-based thermosensitive hydrogels including modified chitosan and blend hydrogel are summarized. Also summarizes the applications of those hydrogel in tissue engineering (repair of cartilage, blood vessels and nerve) and drug delivery release (controlled release of cancer drugs, diabetes treatment), in order to provide a reference for further research on the thermosensitive hydrogels.

Key words： Chitosan Thermosensitive hydrogel Tissue engineering Drug release

Received: 19 January 2018 Published: 05 June 2018

ZTFLH:

Q819

Corresponding Authors: Shu-lin YANG E-mail: yshulin@njust.edu.cn

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Cite this article:

Xi KANG,Ai-peng DENG,Shu-lin YANG. Research Progress of Chitosan Based Thermosensitive Hydrogels. China Biotechnology, 2018, 38(5): 79-84.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20180511 OR https://manu60.magtech.com.cn/biotech/Y2018/V38/I5/79


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