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| Long Noncoding RNA and Its Relationship with Cancer |
| LOU Liang-liang1, ZHU Yun-feng1,2 |
1. The Institute of Life Science and Bio-Engineering,Beijing Jiaotong University,Beijing 100044,China;
2. The Key Laboratory in Tumor Center of PLA General Hospital, Beijing 100853, China |
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Abstract The data from human genome indicated that coding sequences are less than 2% and rest of them are considered to be non-coding sequences. The transcripts derived from non-coding sequences are termed as non-coding RNA. Based on the length of non-coding RNAs (ncRNAs), ncRNAs are categorized into long non-coding RNA(lncRNA, greater than 200 nt)and short non-coding RNA(sncRNA). Most lncRNAs are transcribed by RNA polymerase Ⅱ, which make them have some characters of mRNA, eg: 3' polyadenylation tail and 5' CAP structure. In human,lncRNAs are identified to have a wide distribution in genome and some of which may contribute to tumorigenesis and development. The feature of lncRNAs and their functions in tumor cells were focused in this review.
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Received: 15 April 2013
Published: 25 July 2013
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