Research Progress of Optogenetic Techniques

doi:10.13523/j.cb.20190311

China Biotechnology

2019, Vol. 39

Issue (3): 87-96 DOI: 10.13523/j.cb.20190311

Research Progress of Optogenetic Techniques

Xuan-tong GUO¹,Chun-bo ZHANG^2,^**(

)

1 Nanchang Joint Programme, Queen Mary University of London, Nanchang 330031, China
2 School of Pharmacy, Nanchang University, Nanchang 330031, China

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Abstract

Optogenetics is an emerging biological technique that combines optics and genetics to precisely control specific cells within organisms. Since the application of microbial opsins, optogenetics has gained substantial progresses in discovering opsins, optic-control methods and genetic strategies that are based on viruses and recombinases. Optogenetics apply widely in modern neuroscience, playing important roles in the study of neural circuits and behavior, the pathological mechanism of various central nervous system diseases and psychiatric disorders. This review summarizes the development of optogenetic techniques, meanwhile emphasizes the latest advances in the opsin exploration and localized expression, aiming to provide references for research in optogenetics and related fields.

Key words： Optogenetic techniques Light control Opsin Neurobiology

Received: 01 August 2018 Published: 12 April 2019

ZTFLH:

Q819

Corresponding Authors: Chun-bo ZHANG E-mail: cbzhang@ncu.edu.cn

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Cite this article:

Xuan-tong GUO,Chun-bo ZHANG. Research Progress of Optogenetic Techniques. China Biotechnology, 2019, 39(3): 87-96.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20190311 OR https://manu60.magtech.com.cn/biotech/Y2019/V39/I3/87

Table 1 Characteristic Parameters of Common Opsins

Fig.1 Localized expression technology of opsin^[21]

Fig.2 Activation of opsin expression in mouse brain^[21]


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