The Application of Polymersomes in Drug Delivery System

doi:10.13523/j.cb.20190609

China Biotechnology

2019, Vol. 39

Issue (6): 62-72 DOI: 10.13523/j.cb.20190609

The Application of Polymersomes in Drug Delivery System

Wen-jie CAO¹,Xiang-yuan XIONG^1,^2,^**(

),Yan-chun GONG²,Zi-ling LI²,Yu-ping LI²

1 School of Pharmacy, Jiangxi Normal University of Science and Technology, Nanchang 330013,China
2 School of Life Sciences,Jiangxi Normal University of Science and Technology,Nanchang 330013,China

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Abstract

As a novel kind of nano-drug carrier, the polymersomes have the characteristics of biodegradability, stability, biocompatibility and modifiable multi-functionalization and so on. Polymersomes can be prepared by changing polymer type and the ratio of hydrophilic - hydrophobic block, which possess different morphological and membrane properties. After modifiing polymersomes, more functions can be given to realize the ability of controlling drug release and targeting drugs. The structure, composition, preparation methods and the application of drug delivery system about polymersomes have been reviewed in detail. The purpose is to know the latest research progress of polymersomes and some important problems in this field need to be solved by scientists in the future.

Key words： Polymersomes Drug delivery system Amphiphilic block copolymer Controlled release Target

Received: 13 November 2018 Published: 12 July 2019

ZTFLH:

Q819

Corresponding Authors: Xiang-yuan XIONG E-mail: xyxiong@gmail.com

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	Yu-ping LI

Cite this article:

Wen-jie CAO,Xiang-yuan XIONG,Yan-chun GONG,Zi-ling LI,Yu-ping LI. The Application of Polymersomes in Drug Delivery System. China Biotechnology, 2019, 39(6): 62-72.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20190609 OR https://manu60.magtech.com.cn/biotech/Y2019/V39/I6/62

Fig.1 Schematic representation of liposomes (left) versus polymersomes (right)

Fig.2 Schematic illustration of a 3D cross-section of a polymersome

Fig.3 Pentablock copolymer molecular formula and its possible microscopic schematic and TEM micrograph (a) Molecular formula (b) Possible schematic microstructure (c) TEM micrograph

Fig.4 PH-triggered transformation of polymersomes

Fig. 5 Shape transformable and thermo-responsive nano-scaffolds in a cancer tissue

Fig.6 Surface functionalised polymersome loaded with hydrophobic and hydrophilic drugs

Table 1 The application of polymersomes in drug delivery system


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