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中国生物工程杂志

China Biotechnology
China Biotechnology  2016, Vol. 36 Issue (2): 109-114    DOI: 10.13523/j.cb.20160216
    
Progress in the Metabolic Engineering of Saccharomyces cerevisiae for L-lactic Acid Production
LIANG Xin-quan, LI Ning, REN Qin, LIU Ji-dong
Light Industry and Food Engineering College, Guangxi University, Nanning 530004, China
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Abstract  

L-lactic acid is one of the key metabolites of microorganism, and has an extensive application value. To date, microbial origins L-lactic acid contribute to the main source of this compound, whereas it is restricted by precise fermentation control, relative low bacterial product tolerance and high substrate requirements, and therefore resulted in L-lactic acid supply deficiency and a higher price. Due to the advantages of Saccharomyces cerevisiae in the production of valuable products with cheap substrate, along with the development of molecular biology technology, more attention has been attracted on the metabolic engineering of S. cerevisiae for higher production of L-lactic acid. Recent research progresses in the production of L-lactic acid in Saccharomyces cerevisiae, including the accumulation of L-lactic acid, the improving of lactate production and cell productivity were presented. Finally, the limitation of current progress and proposed the future research needs for microbial production of L-lactic acid were also discussed.



Key wordsSaccharomyces cerevisiae      Metabolic engineering      L-lactic acid     
Received: 11 September 2015      Published: 19 November 2015
ZTFLH:  Q819  
Cite this article:

LIANG Xin-quan, LI Ning, REN Qin, LIU Ji-dong. Progress in the Metabolic Engineering of Saccharomyces cerevisiae for L-lactic Acid Production. China Biotechnology, 2016, 36(2): 109-114.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20160216     OR     https://manu60.magtech.com.cn/biotech/Y2016/V36/I2/109

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