Production of Cyclic Adenosine Monophosphate (cAMP) by Microbial Fermentation——A Review

doi:10.13523/j.cb.20180215

China Biotechnology

2018, Vol. 38

Issue (2): 102-108 DOI: 10.13523/j.cb.20180215

Orginal Article

Production of Cyclic Adenosine Monophosphate (cAMP) by Microbial Fermentation——A Review

Li-na CHENG^1,²,Hai-yan LU^1,²,Shu-ling QU³,Yi-qun ZHANG³,Juan-juan DING^1,²,Shao-lan ZOU^1,^2*(

)

1 School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China
2 Key Laboratory of Systems Bioengineering,Ministry of Education,Tianjin 300350,China
3 PetroChina Dagang Oilfield In Tuanbowa Development Company, Tianjin 301607, China

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Abstract

3’,5’-cyclic adenosine monophosphate (cAMP), an important and active compound due to its participation in various physiological actions, acts as a key second messenger. It was first reported in 1957. Since then a lot of research had been carried on for its numerous functions. Exogenous cAMP was developed as pharmaceuticals early in 1970s and it has also been proved to have a great potential in animal husbandry. Now the known cAMP API (Active Pharmaceutical Ingredient) was all produced by chemical synthesis. On the other hand, the species used by microbial cAMP fermentation research includes Arthrobacter, Bacillus subtilis and yeast. As a result of utilizing metabolic regulation mechanism and technology, the extracellular cAMP level could reach ≥7.23 g/L for Arthrobacter and 6~7 g/L for Bacillus subtilis. High levels of extracellular cAMP production by Saccharomyces cerevisiae were reported in recent years. In order to make full use of microbial fermentation and realize its industrial production, it needs to further improve the performance of fermenting microorganisms and the fermentation technology, solve the scale-up problem and make the process more economic.

Key words： cAMP Chemical synthesis Microbial fermentation Metabolic engineering

Received: 28 September 2017 Published: 21 March 2018

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	Li-na CHENG
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	Shao-lan ZOU

Cite this article:

Li-na CHENG,Hai-yan LU,Shu-ling QU,Yi-qun ZHANG,Juan-juan DING,Shao-lan ZOU. Production of Cyclic Adenosine Monophosphate (cAMP) by Microbial Fermentation——A Review. China Biotechnology, 2018, 38(2): 102-108.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20180215 OR https://manu60.magtech.com.cn/biotech/Y2018/V38/I2/102

Fig.1 Purine metabolism and cAMP synthesis pathway in Saccharomyces cerevisiae


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