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| Advances in the Synthesis of Odd-chain Fatty Acids by Microorganisms |
BAI Song,HOU Zheng-jie,GAO Geng-rong,QIAO Bin,CHENG Jing-sheng( ) |
| Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300372, China |
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Abstract Odd-chain fatty acids (OCFAs) are widely distributed in nature, while their level is low. OCFA has huge application potential in the fields of medicine, health, and industry. The current methods of obtaining OCFA are mainly included in the extraction and chemical synthesis, which limits its application due to the higher-cost and the lower-efficiency. Microbial fermentation is one of the most promising strategies for large-scale industrial production. This article briefly discusses the scope of application of OCFA, summarizes the microorganisms that can naturally synthesize OCFA, introduces in detail the related metabolic pathways involved in microbial synthesis of OCFA, and reviews the current strategies of genetic engineering and fermentation regulation for improving OCFA production. Taken together, this summary aims to provide a more systematic and comprehensive theoretical basis for improving OCFA production of microorganism by synthetic biology strategies.
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Received: 27 January 2022
Published: 07 July 2022
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Corresponding Authors:
Jing-sheng CHENG
E-mail: jscheng@tju.edu.cn
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