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| Advances in Synthetic Biology of Fungal Aromatic Polyketides |
RAO Hai-mi,LIANG Dong-mei,LI Wei-guo,QIAO Jian-jun,CAI YIN Qing-ge-le( ) |
| Key Laboratory of Systems Bioengineering,Ministry of Education, School of Chemical Engineering,Tianjin University, Tianjin 301700,China |
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Abstract Fungal aromatic polyketides are a class of natural products with a wide range of bio-activite,which catalyzed by fungal non-reducing polyketide synthase (NR-PKSs).Some aromatic polyketide producting strains have problems such as difficulty in cultivation, pathogenicity, or low yield, which fundamentally limit the development and application of fungal aromatic polyketides.With the development of synthetic biology and metabolic engineering, more and more polyketides with biological activity have realized the heterogeneous production of industrial microorganisms(such as Saccharomyces cerevisiae and Aspergillus nidulans,etc.), and related research have gradually become hot spots. The research progress of the synthetic biology of fungal aromatic polyketides in recent years is reviewed from the analysis and mining of biosynthetic pathways, the construction and optimization of chassis cells, etc., which lays the foundation for the efficient synthesis of artificial metabolic pathways of aromatic polyketides and industrial production in the future.
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Received: 09 March 2020
Published: 12 October 2020
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Corresponding Authors:
YIN Qing-ge-le CAI
E-mail: qinggele@tju.edu.cn
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