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| Application and Prospects of Lung Organoid Models in the Study of Infectious Lung Diseases |
SHI Jin1,LIU Ke2,DING Jun-ying2,**( ) |
1 Department of Clinical Laboratory, Beijing Hospital of Traditional Chinese Medicine (TCM), Capital Medical University, Beijing 100010, China
2 Beijing Key Laboratory of Basic Research with TCM on Infectious Diseases, Beijing Institute of Chinese Medicine, Beijing Hospital of TCM, Capital Medical University, Beijing 100010, China |
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Abstract Lung is an important target organ for infection and injury by viruses, bacteria and other pathogens. In recent years, the novel coronavirus epidemic has made us realize that infectious pulmonary diseases pose a serious threat to human health, even life. Due to the urgency of the research on the pathogenesis and prevention mechanism of pulmonary diseases, lung organoids are increasingly becoming effective tools for research in this field due to their characteristics such as accurate simulation, high applicability and no ethical concerns. On the basis of tracing its development, this paper reviews the construction and application of lung organoid models in different infectious pulmonary diseases, and anticipates the future development prospects of the models.
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Received: 13 April 2023
Published: 05 September 2023
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