Research Progress of Function and Biosynthesis of Coumarins

doi:10.13523/j.cb.2207014

China Biotechnology

2022, Vol. 42

Issue (12): 79-90 DOI: 10.13523/j.cb.2207014

Research Progress of Function and Biosynthesis of Coumarins

WANG Rong-xiang^1,²,SONG Jia²,SUN Bo²,YAN Xue³,ZHANG Wan-zhong^1,^**(

),ZHAO Chen^2,^**(

)

1 College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China
2 National Engineering Research Center of Grain Storage and Logistics, Academy of National Food and Strategic Reserves Administration, Beijing 100037, China
3 Key Laboratory of Quality Control for Feed and Products of Livestock and Poultry of Sichuan Province, New Hope Liuhe Limited Company, Chengdu 610023, China

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Abstract

Coumarins are important compounds in nature. They show a wide range of applications, due to their multiple bio-activities such as antitumor, anticoagulation, antibacterial, and insecticidal. At present, most of these compounds are obtained through plant extraction, which is greatly affected by environmental factors, resulting in low yield and high cost, and therefore is not conducive to large-scale production and hinders their application. Instead, the biosynthesis process is controllable. It becomes a research hotspot to develop industrialized production technology of target natural products through optimization of the biosynthetic expression elements, host and fermentation conditions. However, mining of key enzymes in the biosynthetic pathway is still a difficult task in this research field. In this paper, the structure, function and biosynthesis of some coumarins and their derivatives are reviewed, which provides a reference for gene mining and heterologous expression of the synthetic pathways of these compounds.

Key words： Coumarin compounds Biosynthesis Bio-activity Heterologous expression

Received: 08 July 2022 Published: 05 January 2023

ZTFLH:

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Corresponding Authors: Wan-zhong ZHANG,Chen ZHAO E-mail: lzwz2004@sina.com;zc@ags.ac.cn

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	Rong-xiang WANG
	Jia SONG
	Bo SUN
	Xue YAN
	Wan-zhong ZHANG
	Chen ZHAO

Cite this article:

WANG Rong-xiang,SONG Jia,SUN Bo,YAN Xue,ZHANG Wan-zhong,ZHAO Chen. Research Progress of Function and Biosynthesis of Coumarins. China Biotechnology, 2022, 42(12): 79-90.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2207014 OR https://manu60.magtech.com.cn/biotech/Y2022/V42/I12/79

Fig.1 Types and representative compounds of coumarins (a) Coumarin matrix (b) Simple coumarins (c) Linear furanocoumarins (d) Angular furanocoumarins (e) Linear pyranocoumarins (f) Angular pyranocoumarins (g) (h) Other coumarins

Table 1 Structure and function of common coumarin compounds and their derivatives

Fig.2 Biosynthetic pathway of coumarins

Fig.3 Shikimic acid pathway PpsA: Phosphoenolpyruvate synthase; TktA: Transketolase; DAHPS: 3-Deoxy-arabinoheptose-7-phosphate synthetase; DHQS: 3-Dehydroquinate synthase; AroD: 3-Dehydroquinic acid dehydratase; SDH: Shikimate dehydrogenase; AroL/AroK: Shikimate kinase isozyme; EPSPs: 5-Enolpyruvylshikimate-3-phosphate synthase; CS: Chorismate synthase


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