Advances in Microbial Production of Ginsenoside and Its Derivatives

doi:10.13523/j.cb.2010014

China Biotechnology

2021, Vol. 41

Issue (1): 80-93 DOI: 10.13523/j.cb.2010014

Advances in Microbial Production of Ginsenoside and Its Derivatives

LIU Xiao-chen^1,²,FAN Dai-di^1,²,YANG Fan¹,WU Zhan-sheng^1,^**(

)

1 Xian Key Laboratory of Textile Chemical Engineering Auxiliaries, School of Environmental and Chemical Engineering, Xi’an Polytechnic University, Xi’an 710048, China
2 Shaanxi R&D Center of Biomaterials and Fermentation Engineering, College of Chemical Engineering, Northwest University, Xi’an 710069, China

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Abstract

Ginsenosides are the main active substances of traditional medicinal plants and are widely used in the fields of medicine, health care products, nutritional products and cosmetics. In particular, rare ginsenosides have a variety of biological activities, such as significant anti-tumor activity and nervous system protection and liver protection function. However, the low yield of rare ginsenosides in plants seriously affects its development and utilization. Since the end of the 20th century, with the continuous development of biotechnology and genome sequencing, the problem of low production of ginsenosides can be solved by heterologous synthesis of ginsenosides in microorganisms. Therefore, it has attracted more and more attentions such as constructing an artificial synthetic system of ginsenosides, regulating ginsenoside biosynthesis strategies, and increasing the yield of saponinsin microorganisms. We reviewed the construction of heterologous synthetic pathways of ginsenosides and the research progress of their biosynthetic regulation strategies in this review. Finally, we summarized and prospected the future research directions of ginsenosides synthesis process and regulation process in microorganisms.

Key words： Ginsenosides Biosynthesis Gene mining Chassis cells Regulatory strategies

Received: 15 October 2020 Published: 09 February 2021

ZTFLH:

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Corresponding Authors: Zhan-sheng WU E-mail: wuzhans@126.com

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	LIU Xiao-chen
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Cite this article:

LIU Xiao-chen, FAN Dai-di, YANG Fan, WU Zhan-sheng. Advances in Microbial Production of Ginsenoside and Its Derivatives. China Biotechnology, 2021, 41(1): 80-93.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2010014 OR https://manu60.magtech.com.cn/biotech/Y2021/V41/I1/80

Fig.1 Different types of ginsenoside compounds

Fig.2 Biosynthetic pathway of ginsenoside compounds

Table 1 Metabolic intermediates and their structures during ginsenoside biosynthesis

Table 2 Enzymes and their functions in the biosynthesis of ginsenoside

Table 3 Key enzyme gene mining during ginsenoside biosynthesis

Fig.3 Optimization of the modified chassis^[76]


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