耐药菌感染的噬菌体治疗专利技术

doi:10.13523/j.cb.2006052

中国生物工程杂志

2020, Vol. 40

Issue (10): 104-111 DOI: 10.13523/j.cb.2006052

专利

耐药菌感染的噬菌体治疗专利技术

赵建民(

),张思源

国家知识产权局专利局专利审查协作天津中心天津 300304

Review of Patented Bacteriophage Treatment Technology for Drug-Resistant Bacteria Infection

ZHAO Jian-min(

),ZHANG Si-yuan

Patent Examination Cooperation Tianjin Center of the Patent Office, CNIPA, Tianjin 300304, China

全文: PDF(5410 KB) HTML

摘要：

耐药菌,尤其是多重耐药菌的出现和持续进化给人类健康带来了巨大的威胁。在抗生素逐渐失去特效作用的情况下,科学界和医药界又把眼光重新投向了抗菌的天然生物-噬菌体,并在一些研究中证明了噬菌体可以作为新的武器去替代抗生素治疗耐药菌感染。通过对噬菌体治疗及衍生的裂解酶治疗的世界专利申请进行统计及分析,获得了专利发展趋势、申请人分布特点及主要专利申请人等信息,详细分析了噬菌体及裂解酶治疗的主要专利技术路线和研发热点。

关键词： 噬菌体; 裂解酶; 耐药菌; 专利技术

Abstract:

The emergence and continuous evolution of drug-resistant bacteria, especially multi-drug resistant bacteria, poses a huge threat to human health. With the gradual loss of special effects of antibiotics, the scientific community and the medical community have turned their eyes to antibacterial natural organisms-bacteriophage, and in some studies have proved that bacteriophage can be used as a new weapon to replace antibiotics to treat drug-resistant bacterial infections. Through statistics and analysis of the world patent applications of phage therapy and derived lyase therapy, information on patent development trends, applicant distribution characteristics and main patent applicants was obtained, and the main patent technology routes and hotspots of bacteriophage and lyase therapy were analyzed in detail.

Key words: Bacteriophage Lyase Drug-resistant bacteria Patent technology

收稿日期: 2020-06-26 出版日期: 2020-11-10

ZTFLH:

Q819

通讯作者: 赵建民 E-mail: zhaojianmin_163@126.com

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引用本文:

赵建民,张思源. 耐药菌感染的噬菌体治疗专利技术[J]. 中国生物工程杂志, 2020, 40(10): 104-111.

ZHAO Jian-min,ZHANG Si-yuan. Review of Patented Bacteriophage Treatment Technology for Drug-Resistant Bacteria Infection. China Biotechnology, 2020, 40(10): 104-111.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2006052 或 https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I10/104

图1 噬菌体治疗专利发展申请趋势

图2 全球噬菌体治疗专利申请人分布

图3 全球噬菌体治疗领域主要申请人排名

表1 申请量前十申请人的噬菌体相关专利技术主题

图4 全球多重耐药菌的噬菌体治疗专利申请人分布

表2 裂解酶治疗专利

[1]	THACKER P D. Set a microbe to kill a microbe: drug resistance renews interest in phage therapy. JAMA, 2003,290(24):3183-3185. doi: 10.1001/jama.290.24.3183 pmid: 14693857
[2]	安瑞. 噬菌体治疗的前世、今生与未来--对话微生物学界噬菌体专家. 科学通报, 2017,62(23):2577-2580.
	AN R. Phage-based and future:dialogue bacteriophage expert in microbiology. Chin Sci Bulletin, 2017,62(23):2577-2580.
[3]	Andrzej G, Ryszard M, Małgorzata Ł, et al. Phage Therapy: what have we learned? Viruses, 2018,10(6):1-28.
[4]	Derek M L, Britt K, Henry C L. Phage therapy:an alternative to antibiotics in the age of multi-drug resistance. World J Gastrointest Pharmacol Ther, 2017,8(3):162-173. doi: 10.4292/wjgpt.v8.i3.162 pmid: 28828194
[5]	向盈盈, 宋飞, 杨向红, 等. 噬菌体疗法在口腔感染性疾病中的应用. 昆明医科大学学报, 2020,41(6):167-173.
	Xiang Y Y, Song F, Yang X H, et al. Application of phage therapy in oral infectious diseases. Journal of Kunming Medical University, 2020,41(6):167-173.
[6]	Phil T. FDA green lights study of phage-based drug for resistantin fections.[2020-07-19]. http://www.pmlive.com/pharma_news/fda_green_lights_study_of_phage-based_drug_for_resistant_infections_1329139.
[7]	崔泽林, 郭晓奎, 李莉, 等. 噬菌体抗菌治疗安全性评估体系的建立. 微生物学报, 2018,58(11):2033-2039.
	Cui Z L, Guo X K, Li L, et al. Establishment of safety assessment system of phage therapy. Acta Microbiologica Sinica, 2018,58(11):2033-2039.
[8]	Michele M, Lorenzo C. Robust approaches for the production of active ingredient and drug product for human phage therapy. Frontiers in Microbiology, 10:2289. pmid: 31649636
[9]	Duan Y, Llorente C, Lang S, et al. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature, 2019,575(7783):505-511. doi: 10.1038/s41586-019-1742-x pmid: 31723265
[10]	王韧韬, 刘又宁. 噬菌体治疗细菌感染的临床应用与进展. 中华结核和呼吸杂志, 2020,43(6):539-543.
	Wang R T, Liu Y N. The clinical application and progress of bacteriophages in the treatment of bacterial infections. Chin J Tuberc Respir Dis, 2020,43(6):539-543.
[11]	Piuri M, Jacobs W R, Hatfull G F. Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis. PLoS One, 2009,4(3):e4870. doi: 10.1371/journal.pone.0004870 pmid: 19300517
[12]	褚国煜, 李晓宇, 王丽丽, 等. 噬菌体在多重耐药菌创伤性感染治疗中的作用. 国外医药(抗生素分册), 2019,40(5):441-444.
	Chu G Y, Li X L, Wang L L, et al. The role of phage in the treatment of superbugular infections. World Notes on Antibiotics, 2019,40(5):441-444.
[13]	Zahra M, Abdollah G. Modifified phages:novel antimicrobial agents to combat infectious diseases. Biotechnology Advances, 2011,29(6):732-738. doi: 10.1016/j.biotechadv.2011.06.003 pmid: 21689739
[14]	Hugo O, Carlos S, Joana A. Phage-derived peptidoglycan degrading enzymes: challenges and future prospects for in vivo therapy. Viruses, 2018,10(6):1-18.

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