阿尔茨海默症基因研究态势分析

doi:10.13523/j.cb.2006004

中国生物工程杂志

2020, Vol. 40

Issue (10): 112-121 DOI: 10.13523/j.cb.2006004

技术情报

阿尔茨海默症基因研究态势分析

刘耀洲¹,马恺悦¹,魏浩然²,梁腾霄¹,徐元昊³,宋秀芳^4,^5,^*(

)

1 中国科学院大学生命学院北京 100049 2 中国科学院大学材料科学与光电技术学院北京 100049
2 中国科学院大学材料科学与光电技术学院北京 100049
3 中国科学院大学化学科学学院北京 100049
4 中国科学院文献情报中心北京 100190
5 中国科学院大学经济与管理学院北京 100049

Bibliometric Analysis of Gene Research in Alzheimer’s Disease

LIU Yao-zhou¹,MA Kai-yue¹,WEI Hao-ran²,LIANG Teng-xiao¹,XU Yuan-hao³,SONG Xiu-fang^4,^5,^*(

)

1 College of Life Sciences, University of Chinese Academy of Sciences,Beijing 100049,China
2 College of Materials Science and Opto-Electronic Technology,University of Chinese Academy of Sciences, Beijing 100049,China
3 School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049,China
4 National Library of Sciences, Chinese Academy of Sciences, Beijing　100190,China
5 School of Economics and Management, University of Chinese Academy of Sciences, Beijing　100049,China

全文: PDF(39390 KB) HTML

摘要：

阿尔茨海默症是一种起病隐匿的进行性发展的神经系统退行性疾病。随着全球老龄化日趋严重,阿尔茨海默症严重威胁人民的生命健康与生活质量。阿尔茨海默症成因复杂,治疗阿尔茨海默症仍然是重要的医学难题。通过对Web of Science核心合集中收录的阿尔茨海默症基因研究相关的文献,利用文献计量的方法,进行研究趋势、研究人员、研究机构、国家和研究热点等方面进行态势分析,为相关领域的研究人员提供重要的参考。

关键词： 阿尔茨海默症; 文献计量; VOSviewer; 合作分析; 共现分析

Abstract:

Alzheimer’s disease is a progressive neurodegenerative disease with occult onset. With the global aging becoming more and more serious, Alzheimer’s disease is a serious threat to people’s health and quality of life. The causes of Alzheimer’s disease are complex, and the treatment of Alzheimer’s disease is still an important problem in medicine. In this paper, with the literature of Alzheimer’s disease gene research indexed in the core collection of Web of Science, bibliometric analysis of publication trends, researchers, institutions, countries and research hotspots was carried out to provide important reference for researchers in related fields.

Key words: Alzheimer’s disease Bibliometrics VOSviewer Cooperation analysis Cooccurence analysis

收稿日期: 2020-06-03 出版日期: 2020-11-10

ZTFLH:

Q819

通讯作者: 宋秀芳 E-mail: songxf@mail.las.ac.cn

	服务
	把本文推荐给朋友
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	刘耀洲
	马恺悦
	魏浩然
	梁腾霄
	徐元昊
	宋秀芳

引用本文:

刘耀洲,马恺悦,魏浩然,梁腾霄,徐元昊,宋秀芳. 阿尔茨海默症基因研究态势分析[J]. 中国生物工程杂志, 2020, 40(10): 112-121.

LIU Yao-zhou,MA Kai-yue,WEI Hao-ran,LIANG Teng-xiao,XU Yuan-hao,SONG Xiu-fang. Bibliometric Analysis of Gene Research in Alzheimer’s Disease. China Biotechnology, 2020, 40(10): 112-121.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2006004 或 https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I10/112

图1 阿尔茨海默症基因研究每年出版文章数量

图2 阿尔茨海默症基因研究文章出版数量的年增长率

表1 阿尔茨海默症基因研究TOP20发文作者

图3 阿尔茨海默症基因研究TOP20研究人员之间合作关系

图4 阿尔茨海默症基因研究TOP20机构发文情况

图5 阿尔茨海默症基因研究机构合作分析

表2 阿尔茨海默症基因研究TOP10国家对比

图6 阿尔茨海默症基因研究中TOP10国家近10年发文情况

图7 阿尔茨海默症基因研究的国家合作分析

图8 阿尔茨海默症基因研究相关文献的作者关键词共现分析

[1]	Alzheimer A. Uber eine eigenartige erkrankung der hirnrinde. Allgemeine Zeitschrift fur Psychiatrie und phy- chish-Gerichtliche Medizin (Berlin), 1907,64:146-148.
[2]	Monaco A, Amoroso N, Bellantuono L, et al. Shannon entropy approach reveals relevant genes in alzheimer’s disease. PLoS One, 2019; 14(12):e0226190. pmid: 31891941
[3]	Zawia N H, Lahiri D K, Cardozo-Pelaez F. Epigenetics, oxidative stress, and alzheimer disease. Free Radical Biology and Medicine, 2009,46(9):1241-1249. doi: 10.1016/j.freeradbiomed.2009.02.006 pmid: 19245828
[4]	Muller W E, Eckert A, Kurz C, et al. Mitochondrial dysfunction: common final pathway in brain aging and alzheimer’s disease-therapeutic aspects. Molecular Neurobiology, 2010,41(2-3):159-171. doi: 10.1007/s12035-010-8141-5 pmid: 20461558
[5]	Wakabayashi T, Yamaguchi K, Matsui K, et al. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of alzheimer’s disease. Molecular Neurodegeneration, 2019,14(15):1-18. doi: 10.1186/s13024-018-0301-5
[6]	Rana P, Franco E F, Rao Y, et al. Evaluation of the common molecular basis in alzheimer’s and parkinson’s diseases. International Journal of Molecular Sciences, 2019,20(15):3730. doi: 10.3390/ijms20153730
[7]	Herrera-Espejo S, Santos-Zorrozua B, Alvarez-Gonzalez P.. et al. A systematic review of microrna expression as biomarker of late-onset alzheimer’s disease. Molecular Neurobiology, 2019,56(12):8376-8391. doi: 10.1007/s12035-019-01676-9 pmid: 31240600
[8]	Sims R, Hill M, Williams J. The multiplex model of the genetics of alzheimer’s disease. Nature Neuroscience, 2020,23(3):311-322. pmid: 32112059
[9]	Nacmias B, Tedde A, Cellini E, et al. Alpha 2-macroglobulin polymorphisms in italian sporadic and familial alzheimer’s disease. Neuroscience Letters, 2001,299(1-2):9-12. pmid: 11166925
[10]	Wavrant-De Vrieze F, Compton D, Womick M, et al. Abca1 polymorphisms and alzheimer’s disease. Neuroscience Letters, 2007,416(2):180-183. doi: 10.1016/j.neulet.2007.02.010 pmid: 17324514
[11]	Mentis A F A, Dardiotis E, Chrousos G P. Apolipoprotein e4 and meningeal lymphatics in alzheimer disease: a conceptual framework. Molecular Psychiatry, 2020, doi: 10.1038/s41380-020-0731-7. doi: 10.1038/s41380-020-0731-7 pmid: 33070149
[12]	Yuan Q, Wang F, Xue SF. et al. Association of polymorphisms in the lrp1 and a2m genes with alzheimer’s disease in the northern chinese han population. Journal of Clinical Neuroscience, 2013,20(2):247-250.
[13]	Van Uden E, Kang D E, Hoo E H, et al. Ldl receptor-related protein (lrp) in alzheimer’s disease: towards a unified theory of pathogenesis. Microscopy Research and Technique, 2000,50(4):268-272. doi: 10.1002/1097-0029(20000815)50:4<268::AID-JEMT3>3.0.CO;2-1 pmid: 10936878
[14]	Munshi A, Ahuja Y R. Genes associated with alzheimer disease. Neurology Asia, 2010,15(2):109-118.
[15]	Lonneborg A. Biomarkers for alzheimer disease in cerebrospinal fluid, urine, and blood. Molecular Diagnosis & Therapy, 2008,12(5):307-320. pmid: 18803429
[16]	Misra A, Chakrabarti S S, Gambhir I S. New genetic players in late-onset alzheimer’s disease: findings of genome-wide association studies. Indian Journal of Medical Research, 2018,148(2):135-144. doi: 10.4103/ijmr.IJMR_473_17 pmid: 30381536
[17]	Carrasquillo M M, Belbin O, Hunter T A. et al. Replication of bin1 association with alzheimer’s disease and evaluation of genetic interactions. Journal of Alzheimers Disease, 2011,24(4):751-758.
[18]	Rohn T T. The triggering receptor expressed on myeloid cells 2: “Trem-ming” the inflammatory component associated with alzheimer’s disease. Oxidative Medicine and Cellular Longevity, 2013,2013:1-8.
[19]	Lambert J C, Heath S, Even G, et al. Genome-wide association study identifies variants at clu and cr1 associated with alzheimer’s disease. Nature Genetics, 2009,41(10):1094-U1068. doi: 10.1038/ng.439 pmid: 19734903
[20]	Ray M, Zhang W X. Analysis of alzheimer’s disease severity across brain regions by topological analysis of gene co-expression networks. Bmc Systems Biology, 2010,4:136. doi: 10.1186/1752-0509-4-136 pmid: 20925940
[21]	Ham S, Kim T K, Ryu J, et al. Comprehensive micrornaome analysis of the relationship between alzheimer disease and cancer in psen double-knockout mice. International Neurourology Journal, 2018,22(4):237-245. doi: 10.5213/inj.1836274.137 pmid: 30599494
[22]	Checler F. Presenilins: multifunctional proteins involved in alzheimer’s disease pathology. Lubmb Life, 1999,48(1):33-39. doi: 10.1080/713803480 pmid: 10791913
[23]	Senanarong V, An S S A, Giau V V. et al. Pathogenic psen1 glu184gly mutation in a family from thailand with probable autosomal dominant early onset alzheimer’s disease. Diagnostics, 2020,10(3):135.

[1]	马丽丽,易盼盼,敖妮花,焦洪涛,雷瑞鹏,刘欢. 基于学科类别和富集分析的生物安全研究领域学科交叉研究^*[J]. 中国生物工程杂志, 2021, 41(12): 116-124.
[2]	白京羽,林晓锋,尹政清. 基于文献计量的全球生物技术研究现状与发展趋势分析[J]. 中国生物工程杂志, 2020, 40(7): 100-109.
[3]	巩玥,廖青云,于倩倩,史志祥,陈菁,张宇辉,赵光慧. 冠状病毒研究态势分析[J]. 中国生物工程杂志, 2020, 40(1-2): 21-37.
[4]	赵勇,孙成权,沙勇忠. 国际生物制氢相关研究的知识图谱分析[J]. 中国生物工程杂志, 2009, 29(01): 116-121.

Viewed

Full text

Abstract

Cited

Shared

Discussed