中国生物工程杂志

[1] Singh V. Recent advancements in synthetic biology: Current status and challenges. Gene, 2014, 535 (1): 1-11.

[2] 张春霆.合成生物学研究的进展.中国科学基金, 2009, 23 (2): 65-69. Zhang C T. Advances in synthetic biology. Bulletin of National Natural Science Foundation of China, 2009, 23 (2): 65-69.

[3] Fu J, Bian X Y, Hu S B, et al. Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nature Biotechnology, 2012, 30 (5): 440-448.

[4] Su C, Zhao X Q, Wang H N, et al. Seamless stitching of biosynthetic gene cluster containing type I polyketide synthases using Red/ET mediated recombination for construction of stably co-existing plasmids. Gene, 2014, 554 (2): 233-240.

[5] Shao Z Y, Zhao H M. DNA assembler: a synthetic biology tool for characterizing and engineering natural product gene clusters. Methods in Enzymology, 2012, 517: 203-224.

[6] Shao Z Y, Luo Y Z, Zhao H M. Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler. Molecular BioSystems, 2011, 7 (4): 1056-1059.

[7] Luo Y, Huang H, Liang J, et al. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster. Nature Communications, 2013, 4 (2894): 1-15.

[8] Yamanaka K, Reynolds K A, Kersten R D, et al. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proceedings of the National Academy of Sciences (USA), 2014, 111 (5): 1957-1962.

[9] Komatsu M, Uchiyama T, Omura S, et al. Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proceedings of the National Academy of Sciences, 2010, 107 (6): 2646-2651.

[10] Komatsu M, Komatsu K, Koiwai H, et al. Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. American Chemical Society Synthetic Biology, 2013, 2 (7): 384-396.

[11] Ikeda H, Kazuo S Y, Omura S. Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters. Journal of Industrial Microbiology Biotechnology, 2014, 41 (2): 233-250.

[12] Gomez-Escribano J P, Bibb M J. Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters. Microbial Biotechnology, 2011, 4 (2): 207-215.

[13] Zhou M, Jing X Y, Xie P F, et al. Sequential deletion of all the polyketide synthase and nonribosomal peptide synthetase biosynthetic gene clusters and a 900kb subtelomeric sequence of the linear chromosome of Streptomyces coelicolor. Federation of European Microbiological Societies Microbiology Letters, 2012, 333 (2): 169-179.

[14] Dange V, Westrich L, Smith M C, et al. Use of an inducible promoter for antibiotic production in a heterologous host. Applied Microbiology and Biotechnology, 2010, 87 (1): 261-269.

[15] Liu H B, Jiang H, Haltli Bradley, et al. Rapid cloning and heterologous expression of the meridamycin biosynthetic gene cluster using a versatile Escherichia coli-Streptomyces artificial chromosome vector, pSBAC. Journal of Natural Products, 2009, 72 (3): 389-395.

[16] Du D, Zhu Y, Wei J, et al. Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters. Applied Microbiology and Biotechnology, 2013, 97 (14): 6383-6396.

[17] Wang W, Li X, Wang J, et al. An engineered strong promoter for streptomycetes. Applied and Environmental Microbiology, 2013, 79 (14): 4484-4492.

[18] Siegl T, Tokovenko B, Myronovskyi M, et al. Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes. Metabolic Engineering, 2013, 19: 98-106.

[19] Zhao X Q, Gust B, Heide L. S-adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces. Archives of Microbiology, 2010, 192 (4): 289-297.

[20] Zhao X J, Wang Q X, Guo W Q, et al. Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains. World Journal of Microbiology and Biotechnology, 2013, 29 (10): 1869-1875.

[21] Kotowska M, Pawlik K. Roles of type II thioesterases and their application for secondary metabolite yield improvement. Applied Microbiology and Biotechnology, 2014, 98 (18): 7735-7746.

[22] Li L, Wu J, Deng Z X, et al. Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S producing strain for ease of genetic manipulation. Applied and Environmental Microbiology, 2013, 79 (7): 2349-2357.

[23] Isaacs F J, Carr P A, Wang H H, et al. Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science, 2011, 333 (6040): 348-353.

[24] Mali P, Esvelt K M, Church G M. Cas 9 as a versatile tool for engineering biology. Nature Methods, 2013, 10 (10): 957-963.

[25] Annaluru N, Muller H, Mitchell L A, et al. Total synthesis of a functional designer eukaryotic chromosome. Science, 2014, 344 (6179): 55-58.

[26] Xu P, Li L, Zhang F, et al. Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Proceedings of the National Academy of Sciences, 2014, 111 (31): 11299-11304.