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| Research Progress of Application and Biosynthesis of Steviol Glycosides |
LI Ya-tong1,MA Yuan-yuan2,3,**( ),WANG Zhen-yang4,SONG Hao1,5,**() |
1 School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
2 School of Marine Science and Technology, Tianjin University, Tianjin 300072, China
3 Tianjin R&D Center for Petrochemical Technology, Tianjin University, Tianjin 300072, China
4 R&D Division, Sinochem Health Company Ltd., Qingdao 266071, China
5 Qingdao Institute of Ocean Engineering of Tianjin University Ltd., Qingdao 266237, China |
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Abstract Steviol glycosides are high-sweetness and zero-calorie sweeteners extracted from Stevia leaves. They can be used as food additives, and their demand in domestic and foreign markets has increased sharply, drawing widespread attention. The review discusses the safety research and evaluation of steviol glycosides in the world and analyzes the market demand and prospects of steviol glycosides from the perspective of economic value. Then, it summarizes the application of steviol glycosides as a sweetener in food and the latest research results in their anti-diabetic, anti-cardiac fibrosis, anti-bacterial and other health-care functions. The research progress in the production, preparation and biosynthesis of steviol glycosides is reviewed, with an emphasis on their de novo synthesis in microorganisms, and the latest progress in the biocatalytic conversion of low-sweet glycosides to produce steviol glycosides with higher sweetness and better taste. Finally, several key strategies for improving production of steviol glycosides are mentioned, and their future development prospects are discussed, providing a theoretical basis for the research and development of green synthesis process of high-end sweeteners.
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Received: 06 May 2022
Published: 14 February 2023
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