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| A Review of Studies on Streptonigrin |
Meng-ying OU1,Xiao-zheng WANG2,Shuang-jun LIN2,Tong-wei GUAN1,**( ),Yi-jin LIN1 |
1 Xihua University Institute of Microbiology, School of Food Science and Biotechnology, Xihua University,Chengdu 610039,China
2 State Key Laboratory of Microbial Metabolism, School of Life Science and Technology, Shanghai Jiaotong University, Shanghai 200240,China |
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Abstract Streptonigrin (STN) is an anti-tumor antibiotic with a unique aminoquinolinium structure produced by Streptomyces flocculus, which has good control effect and broad application prospects in cancer treatment. However, the clinical application of STN has been limited because of its relatively significant myelosuppression side effect.The anti-tumor mechanism, structural features and existing knowledge related to the biosynthesis of streptonigrin and its analogs, including research status and prospects of reducing toxic side effects have been summarized, and providing a scientific reference for the development of low or non-toxic streptonigrin and its analogues.
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Received: 15 December 2018
Published: 05 August 2019
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Corresponding Authors:
Tong-wei GUAN
E-mail: guantongweily@163.com
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