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| Progress of Heterologous Biosynthesis of Terpenoids in Engineered Corynebacterium glutamicum |
Shuo XU,Wen-yu LU( ) |
| Department of Biological Engineering, School of Chemical Engineering and Technology, Tianjin University, Key Laboratory of Systems Bioengineering, Ministry of Education, SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China |
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Abstract Terpenoids have considerable commercial value, but the production process is complex and the yield is low. It has become a hot spot to synthesize terpenoids from microorganism. Corynebacterium glutamicum contains a pathway to produce carotenoid, which is a natural advantage for the synthesis of terpenoids heterologously. The synthesis of terpenoids from C. glutamicum is summarized, including the terpenoids synthesis pathway in C. glutamicum, key enzymes and global regulatory mechanisms in this pathway. And the advances in this pathway in synthesis of monoterpenes, sesquiterpenes, and tetraterpenes are summarized. The problems and advice efficient synthesis of terpenoids by C. glutamicum is discussed.
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Received: 02 November 2018
Published: 12 July 2019
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Corresponding Authors:
Wen-yu LU
E-mail: wenyulu@tju.edu.cn
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