Progress in the Construction and Application of Organoids

doi:10.13523/j.cb.2010002

China Biotechnology

2020, Vol. 40

Issue (12): 82-87 DOI: 10.13523/j.cb.2010002

Progress in the Construction and Application of Organoids

HE Xun^1,^**(

),ZHANG Peng²,ZHANG Jun-xiang³

1 Shenzhen Sinobioway XinPeng biomedicine co., LTD, Beijing 518057, China
2 National Local Joint Engineering Laboratory of Animal Peptide Drug Development, Hunan Normal University,Changsha 410081, China
3 SINOBIOWAY GROUP CO., LTD, Beijing 100085, China

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Abstract

Organoids are driven by stem cells in vitro to form multicellular three-dimensional structures with the micro-anatomical and self-renewing characteristics of the source organs. Organoids produce organ-specific cell types that can reproduce part of the function and spatial structure of the corresponding organs. They promote the development of life medicine research and have shown broad application prospects in cancer basic and clinical research, regenerative medicine and other fields. This review summarizes the research progress of organoids in recent years, including introducing its construction process and culture system and expounding its advantages and disadvantages as an in vitro research model, which provides a reference for scientific research and application based on organoids.

Key words： Organoid Tumor Construction

Received: 10 October 2020 Published: 14 January 2021

ZTFLH:

Q819

Corresponding Authors: Xun HE E-mail: hexun168@sina.com

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Cite this article:

HE Xun,ZHANG Peng,ZHANG Jun-xiang. Progress in the Construction and Application of Organoids. China Biotechnology, 2020, 40(12): 82-87.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2010002 OR https://manu60.magtech.com.cn/biotech/Y2020/V40/I12/82

Table 1 Factors required for the culture of some different tissue-derived organoids

Table 2 Comparison of the main features of preclinical cancer models in the application of anticancer drug screening


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