Preparation and Application of Janus Nanoparticles in Drug Delivery System

doi:10.13523/j.cb.1912042

China Biotechnology

2020, Vol. 40

Issue (7): 70-81 DOI: 10.13523/j.cb.1912042

Preparation and Application of Janus Nanoparticles in Drug Delivery System

YANG Wei^1,²,SONG Fang-xiang³,WANG Shuai^1,²,ZHANG Li³,WANG Hong-xia³,LI Yan^1,^2,^**(

)

1 School of Pharmacy,Guizhou University, Guiyang 550025, China
2 Key Laboratory of Pharmaceutical Synthesis,Guizhou University, Guiyang 550025, China
3 School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China

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Abstract

Janus nanoparticles (JNPs) are used to describe a heterogeneous solid material composed of two different sides. Each side of JNPs is different in chemical nature and/or polarity, and can combine the characteristics and functions of different materials, which is difficult to achieve with homogeneous materials of the same kind. In recent years, major breakthroughs have been made in the preparation of JNPs, but the development direction of its application is still a challenging field, among which the research in the field of antitumor drug delivery systems is more prominent. The preparation method and application of Janus nanoparticles in drug delivery system, and puts forward the research prospects and possible challenges were mainly introduced.

Key words： Janus nanoparticles Preparation Anti-tumor Drug delivery

Received: 23 December 2019 Published: 13 August 2020

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Corresponding Authors: Yan LI E-mail: yanli@gzu.edu.cn

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Cite this article:

YANG Wei,SONG Fang-xiang,WANG Shuai,ZHANG Li,WANG Hong-xia,LI Yan. Preparation and Application of Janus Nanoparticles in Drug Delivery System. China Biotechnology, 2020, 40(7): 70-81.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.1912042 OR https://manu60.magtech.com.cn/biotech/Y2020/V40/I7/70

Fig.1 Different Types of Janus nanoparticles

Fig.2 Mechanism of action of dual targeting MSN: cell targeting and mitochondrial targeting

Fig.3 Preparation of SPIONs as a multifunctional JNPs for targeted drug delivery systems

Fig.4 Preparation modification and application principle of AuNC/Fe(OH)₃-PAA JNPs

Fig.5 Schematic illustration of the FA-targeted Janus nanoparticles with the NIR irradiation-triggered release behavior of ICG and silver ions for synergistic liver cancer chemo/photothermal therapy

Fig.6 Loquat-like Janus drug delivery system (a) The schematic diagrams for loquat, GS and JGS respectively (b)-(d) The SEM image of G, GS and JGS, respectively

Fig.7 Representation of nanodevice N1 based on Janus AuNSt-MSNP and NIR light triggered drug delivery mechanism by photo-dissociation of 2-nitrobenzyl derivative 5

Fig.8 The preparation process of snowman-like Janus nanoparticles (a) Schematic showing the controlled synthetic strategy for obtaining Au/Fe₃O₄@C JNPs (b) Selective modification of Au/Fe₃O₄ @C JNP

Fig.9 Synthesis route and application of Au@Ag nanorod@ZIF-8 nanoparticle (NPs)

Fig.10 Synthesis of Janus mesoporous silica nanocomposites by anisotropic island growth

Table 1 Composition, morphology, preparation methods, drug loading rate and analysis of tumor cell activity of Janus nanoparticles for different types of drug delivery


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