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Research Progress on Vesicular Stomatitis Virus-based Oncolytic Virotherapy |
ZHANG Bao-hui1,3,XIONG Hua-long2,3,ZHANG Tian-ying1,3,**(),YUAN Quan1,3 |
1 School of Public Health, Xiamen University, Xiamen 361102, China 2 School of Life Sciences, Xiamen University, Xiamen 361102, China 3 National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen 361102, China |
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Abstract Oncolytic virus utilizes the characteristics of tumor cells, such as deficiency of antiviral signaling pathway or overexpressing viral receptors, to preferentially infect, replicate in and kill tumor cells, which are emerging as important agents in cancer treatment. Due to the lack of interferon signaling pathways, tumor cells can be specifically targeted by vesicular stomatitis virus (VSV). VSV-based platform shows high prospects, as its efficient replication, broad tissue tropism, low pathogenicity to humans and its small and easy-to-manipulate genome. The virological characteristics of vesicular stomatitis virus and the current research progress of VSV-based oncolytic virus to improve tumor selectivity, extend half-life and increase oncolytic efficacy are discussed in this review.
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Received: 03 January 2020
Published: 23 June 2020
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Corresponding Authors:
Tian-ying ZHANG
E-mail: tyzhang1003@163.com
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