Please wait a minute...

中国生物工程杂志

China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (11): 70-76    DOI: 10.13523/j.cb.20151110
    
Autophagy and Cancer
JING Yuan-ya1, CHEN Ping1, CHANG Jian-feng1, CHEN Su1,2,3
1. School of Life Sciences and Technology, Advanced Institute of Translational Medicine, Research Center for Translational Medicine at East Hospital, Tongji University, Shanghai 200092, China;
2. School of Forensic Sciences, Xi'an Jiao Tong University Health Science Center, Xi'an 710061, China;
3. People's Hospital of Zunhua, Tangshan 064200, China
Download: HTML   PDF(498KB) HTML
Export: BibTeX | EndNote (RIS)      

Abstract  

Autophagy is one of the lysosomal degradation pathways, which plays critical roles in multiple physiological processes in eukaryotes. In recent years, it has been believed that autophagy is tightly involved in tumorigenesis and development. The effects of autophagy on cancer are controversial. Autophagy prevents cells from oxidative stress, persistent inflammation, and DNA damage accumulation during carcinogenesis, and eventually inhibits the development of cancer. However, autophagy also provides growth metabolites needed for tumour cells, and maintains the balance of the intracellular environment, thus promoting carcinogenesis. Autophagy also has double-edged effects on cancer therapy: on one hand, induction of autophagy prevents the accumulation of DNA damages and mutations induced by chemotherapy or radiotherapy, and then inhibits cancer progression; on the other hand, autophagy is required for tumor cells to relieve drug and irradiation therapeutic pressures, and potentially contributes to the survival of tumor cells.



Key wordsCancer therapy      Tumorigenesis      Autophagy     
Received: 13 May 2015      Published: 24 November 2015
ZTFLH:  Q291  
Cite this article:

JING Yuan-ya, CHEN Ping, CHANG Jian-feng, CHEN Su. Autophagy and Cancer. China Biotechnology, 2015, 35(11): 70-76.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20151110     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I11/70

[1] Lozy F, Karantza V. Autophagy and cancer cell metabolism. Semin Cell Dev Biol, 2012, 23(4): 395-401.
[2] Zhou S, Zhao L, Kuang M, et al. Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde. Cancer Lett, 2012, 323(2): 115-127.
[3] Adam M F, Gabalski E C, Bloch D A, et al. Tissue oxygen distribution in head and neck cancer patients. Head Neck, 1999, 21(2): 146-153.
[4] Jin S, White E. Role of autophagy in cancer: management of metabolic stress. Autophagy, 2007, 3(1):28-31.
[5] Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA, 2003, 100(25): 15077-15082.
[6] Takahashi Y, Coppola D, Matsushita N, et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tomorigenesis. Nat Cell Biol, 2007, 9(10): 1142-1151.
[7] Zhi X Y, Zhong Q. Autophagy in cancer. F1000Prime Rep, 2015, 7(18): 1-12.
[8] Vinod V, Padmakrishnan C J, Vijayan B, et al. "How can I halt thee?" The puzzles involved in autophagic inhibition. Pharmacol Res, 2014, 82: 1-8.
[9] Kung C P, Budina A, Balaburski G, et al. Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr, 2011, 21(1): 71-100.
[10] Takahashi Y, Coppola D, Matsushita N, et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol, 2007, 9(10):1142-1151
[11] Miracco C,Cosci E, Oliveri G, et al. Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol, 2007, 30(2): 429-436.
[12] Kang M R, Kim M S, Oh J E, et al. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. J Pathol, 2009, 217(5): 702-706.
[13] Kim M S, Jeong E G, Ahn C H, et al. Frameshift mutation of UVRAG, an autophagy -related gene, in gastric carcinomas with microsatellite instability. Hum Pathol, 2008, 39(7): 1059-1063.
[14] Hoyer-Hansen M, Jäättelä M. Autophagy: an emerging target for cancer trerapy. Autophagy, 2008, 4(5): 547-580.
[15] Wang N, Feng Y B. Elaborating the role of natural products-induced autophagy in cancer treatment: achievements and artifacts in the state of the art. .http://www.hindawi.com/joumals/bmri/2015/934207/.
[16] Xiao K, Jiang J, Guan C, et al. Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells, Journal of Pharmacological Sciences, 2013, 123(2): 102-109.
[17] Hsu C M, Tsai Y, Wan L, et al. Bufalin induces G2/M phase arrest and triggers autophagy via the TNF, JNK, BECN1 and ATG8 pathway in human hepatoma cells. International Journal of Oncology, 2013, 43(1): 338-348.
[18] Chen M, Du Y, Qui M, et al. Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncology Reports, 2013, 29(2): 430-436.
[19] Dong Y, Yin S, Jiang C, et al. Involvement of autophagy induction in penta-1,2,3,4,6-O-galloyl-β-D-glucose-induced senescence-like growth arrest in human cancer cells. Autophagy, 2014, 10(2): 296-310.
[20] Xue W, Zender L, Miething C, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature, 2007, 445(7128): 656-660.
[21] Young A R, Narita M, Ferreira M, et al. Autophagy mediates the mitotic senescence transition. Genes Dev, 2009, 23(7): 798-803.
[22] Li L, Ishdorj G, Gibson S B. Reactive oxygen species regulation of autophagy in cancer: implications for cancer treatment. Free Radic Biol Med, 2012, 53(7): 1399-1410.
[23] Kongara S, Kravchuk O, Teplova I, et al. Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors. Mol Cancer Res, 2010, 8(6): 873-884.
[24] 肖孟景, 李利根. 自噬调控过度炎症研究进展, 生理学报, 2014, 66(6): 739-745. Xiao M J, Li L G. Research progress on autophagy regulating excessive inflammation. Acta Physiologica Sinica, 2014, 66(6):739-745.
[25] Shi C S, Shenderov K, Huang N N, et al. Activation of autophagy by inflammatory signals limits IL-1 beta production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol, 2012, 13(3): 255-263.
[26] Paul S, Kashyap A K, Jia W, et al. Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-kappaB. Immunity, 2012, 36(6): 947-958.
[27] Inomata M, Niida S, Shibata K, et al. Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20. Cell Mol Life Sci, 2012, 69(6): 963-979.
[28] Mathew R, Karantza-Wadsworth V, White E. Role of autophagy in cancer. Nat Rev Cancer, 2007, 7(12): 961-967.
[29] Degenhardt K, Mathew R, Beaudoin B, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell, 2006, 10(1): 51-64.
[30] Li Y, Wang L X, Yang G, et al. Efficient cross-presentation depends on autophagy in tumor cells. Cancer Res, 2008, 68(17): 6889-6895.
[31] Walsh C M, Edinger A L. The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis. Immunol, 2010, 236(1): 95-109.
[32] Pua H H, Dzhagalov I, Chuck M, et al. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med, 2007, 204(1): 25-31.
[33] Pua H H, He Y W. Maintaining T lymphocyte homeostasis: another duty of autophagy. Autophagy, 2007, 3(3): 266-267.
[34] Pua H H, Guo J, Komatsu M, et al. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol, 2009, 182(7): 4046-4055.
[35] Stephenson L M, Miller B C, Ng A, et al. Identification of Arg5-dependent transcriptional changes and increases in mitochondrial mass in Arg5-deficient T lymphocytes. Autophagy, 2009, 5(5): 625-635.
[36] Nedjic J, Aichinger M, Emmerich J, et al. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature, 2008, 455(7211):396-400.
[37] 王赟, 柯飞, 赵安芳,等. 自噬在癌症发生中的双重作用. 癌变·畸变·突变, 2013, 25(6): 481-483. Wang Y, Ke F, Zhao A F, et al. The dual functions of autophagy in carcinogenesis. Carcinogenesis,Teratogenesis and Mutagenesis, 2013, 25(6): 481-483.
[38] LeeJ, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J, 2012, 441(2): 523-540.
[39] Green D R, Levine B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell, 2014, 157(1): 65-75.
[40] Denardo D G, Barreto J B, Andreu P, et al. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell, 2009, 16(2): 91-102.
[41] 葛军娜, 黄丹, 肖田,等. 饥饿诱导肿瘤自噬对细胞周期的影响. 癌症, 2008, 17(8): 788-794. Ge J N, Huang D, Xiao T, et al. Effect of Starvation-induced autophagy on cell cycle of tumor cells. Chinese Journal of Cancer, 2008, 17(8): 788-794.
[42] Avalos Y, Canales J, Bravo S R, et al. Tumor suppression and promotion by autophagy. BioMed Res Int, 2014, 2014(9):603980.
[43] Jiang P, Mizushima N. Autophagy and human diseases, Cell Res, 2014, 24(1): 69-79.
[44] Rosenfeld M R, Ye X, Supko J G, et al. A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy, 2014, 10(8): 1359-1368.
[45] Rangwala R, Leone R, Chang Y C, et al. Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma. Autophagy, 2014, 10(8): 1369-1379.
[46] Yang A, Rajeshkumar N V, Wang X, et al. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov, 2014, 4(8): 905-913.
[47] 王梅,李庆林. 自噬与癌症的治疗. 安徽医药, 2010, 14(8): 869-873. Wang M, Li Q L. Autophagy and the cure of cancer. Anhui Medical and Pharmaceutical Journal, 2010, 14(8): 869-873.
[48] 相建峰, 林盛明, 相燕洁,等. 细胞自噬与肿瘤治疗. 中国中西医结合影像学杂志, 2012, 10(2): 174-176. Xiang J F, Lin S M, Xiang Y J, et al. Autophagy and tumor therapy. Chinese Imaging Journal of Integrated Traditional and Western Medicine, 2012, 10(2): 174-176.
[49] Zou Z Z, Yuan Z Y, Zhang Q X, et al. Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy, 2012, 8(12): 1798-1810.
[50] Selvakumaran M, Amaravadi R K, Vasilevskaya I A, et al. Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy. Clin Cancer Res, 2013, 19(11): 2995-3007.
[51] Cufi S, Vazquez M A, Oliveras F C, et al. The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer. Sci Rep, 2013, 3: 2469.
[52] Shen J, Zheng H, Ruan J, et al. Autophagy inhibition induces enhanced proapoptotic effects of ZD6474 in glioblastoma. Br J Cancer, 2013, 109(1): 164-171.
[53] Zinn R L, Gardner E E, Dobromilskaya I, et al. Combination treatment with ABT-737 and chlorolquine in preclinical models of small cell lung cancer. Mol Cancer, 2013, 12(1): 16.
[54] Maes H, Kuchnio A, Peric A, et al. Tumor vessel normalization by chloroquine independent of autophagy. Cancer Cell, 2014, 26(2): 190-206.
[55] Parzych K R, Klionsky D J. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal, 2014, 20(3):460-473.
[56] 邹争志, 聂培培, 倪艺榕,等. 硫链丝菌素诱导非小细胞肺癌细胞自噬性死亡. 激光生物学报, 2014, 23(1): 33-37. Zou Z Z, Nie P P, Ni Y R, et al. Thiostrepton induces autophagic cell death in non-small-cell lung cancer cells. ACTA Laser Biology Sinica, 2014, 23(1): 33-37.
[57] Cheng Y, Qiu F, Huang J, et al. Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death.Archives of Biochemistry and Biophysics, 2008, 475(2): 55-148.
[58] Li X Q, Lu Y, Pan T H, et al. Roles of autophagy in cetuximab-mediated cancer therapy against EGFR. Autophagy, 2010, 6(8): 1066-1077.

[1] LI Xiao-jin,LI Yan-meng,LI Zhen-kun,XU An-jian,YANG Xiao-xi,HUANG Jian. The Mechanism of Copper Accumulation Induced Autophagy in Hepatocytes of ATP7B-deficient Mice Based on RNA-sequencing[J]. China Biotechnology, 2021, 41(9): 10-19.
[2] DONG Xue-ying,LIANG Kai,YE Ke-ying,ZHOU Ce-fan,TANG Jing-feng. Advances in the Regulation of Receptor Tyrosine Kinase on Autophagy[J]. China Biotechnology, 2021, 41(5): 72-78.
[3] CAI Run-ze,WANG Zheng-bo,CHEN Yong-chang. Research Progress of Mecp2 Affecting Metabolic Function in Rett Syndrome[J]. China Biotechnology, 2021, 41(2/3): 89-97.
[4] HAN Xue-yi,LI Yi-fan,LU Yue-da,XIONG Guo-liang,YU Chang-yuan. Preparation of Porphyrin Metal-organic Framework with Autophagy Inhibitory Effect and Its Photodynamic Cancer Treatment[J]. China Biotechnology, 2021, 41(11): 48-54.
[5] ZENG Xiang-Yi,PAN Jie. Progress on Autophagy Regulation of Browning of White Adipose Cells[J]. China Biotechnology, 2020, 40(6): 63-73.
[6] DAI Qi-nan,ZHANG Jing-hong. Advances in Molecular Mechanisms Related to Tumor Multi-drug Resistance, Autophagy, DNA Repair and Tumor Stem Cells[J]. China Biotechnology, 2020, 40(4): 69-77.
[7] ZHU Yongzhao,TAO Jin,REN Meng-meng,XIONG Ran,HE Ya-qin,ZHOU Yu,LU Zhen-hui,DU Yong,YANG Zhi-hong. Autophagy Protects Against Apoptosis of Human Placental Mesenchymal Stem Cells of Fetal Origin Induced by Tumor Necrosis Fator-α[J]. China Biotechnology, 2019, 39(9): 62-67.
[8] Xiao-yan YANG,Jing-dong MAO,Shu-sen LI,Xin-ying ZHANG,Li-yin DU. Advances in Autophagy on the Regulation of Neutrophil Function[J]. China Biotechnology, 2019, 39(6): 84-90.
[9] Dan-tong HONG,Fan ZHANG,Shu-e WANG,Hong-xia WANG,Kun-mei LIU,Guang-xian XU,Zheng-hao HUO,Le GUO. miR-17-5p Targeting Autophagy Related Protein ATG7 Regulates Macrophages against Mycobacterium tuberculosis Infection[J]. China Biotechnology, 2019, 39(6): 1-8.
[10] Yan LIU,Peng DAI,Yun-feng ZHU. Research Progress of Relationship between Exosomes and Autophagosomes[J]. China Biotechnology, 2019, 39(6): 78-83.
[11] Lu WANG,Li-yuan YANG,Yu-ting TANG,Yao TAO,Li LEI,Yi-pei JING,Xue-ke JIANG,Ling ZHANG. Effects of PKM2 Knockdown on Proliferation and Apoptosis of Human Leukemia Cells and Its Potential Mechanism[J]. China Biotechnology, 2019, 39(3): 13-20.
[12] SHEN Bing-lei,WANG Yu-xuan,HAN Shuo,LI Xi,YANG Zhuo-ni-na,ZOU Zi-wen,LIU Juan. Research Progress of Non-coding RNA in Autophagy[J]. China Biotechnology, 2019, 39(12): 56-63.
[13] ZHAN Hui-lu,BAI Ying,ZHUANG Yan,MENG Juan,ZHAO Hai-yang. Research Progress of Autophagy Induced Protection by Nanomaterials[J]. China Biotechnology, 2019, 39(12): 64-72.
[14] LI Sheng. The Induction Effect of Metal Ions for Cell Autophagy[J]. China Biotechnology, 2017, 37(7): 124-132.
[15] WAN Chun-hong, ZHANG Zhi, LI Sheng-na, PENG Yi-yuan, XU Liang-guo. Research Progresses on TRAF7[J]. China Biotechnology, 2016, 36(3): 93-101.