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| Progress on Autophagy Regulation of Browning of White Adipose Cells |
ZENG Xiang-Yi,PAN Jie( ) |
| College of Life Sciences, Shandong Normal University, Jinan 250014, China |
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Abstract Autophagy of adipocytes is mainly in the form of Lipophagy and Mitophagy. Lipophagy reduces lipotoxicity of adipocytes and provides substrate for mitochondria by promoting lipolysis. Mitophagy controls the quantity and quality of mitochondria to affect the function of the cells. Excessive accumulation of white adipose tissues and inflammation caused by inappropriate autophagy regulation can lead to obesity and its related metabolic diseases. The conversion of stored white adipose cells into heat-producing beige cells by browning of white adipocytes is one of the current strategies to prevent obesity. The process of browning of white adipose cells is inseparable from the regulation of autophagy. This article reviews the current research progress on the role of two forms of autophagy in browning of white adipose cells, related signaling pathways, and autophagy-regulated inflammation, with a view to providing reference for the study of anti-obesity and related metabolic diseases.
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Received: 14 January 2020
Published: 23 June 2020
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Corresponding Authors:
Jie PAN
E-mail: jiepan@sdnu.edu.cn
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