Research Progress of Autophagy Induced Protection by Nanomaterials

doi:10.13523/j.cb.20191209

China Biotechnology

2019, Vol. 39

Issue (12): 64-72 DOI: 10.13523/j.cb.20191209

Research Progress of Autophagy Induced Protection by Nanomaterials

ZHAN Hui-lu^1,^2,³,BAI Ying^1,²,ZHUANG Yan^1,²,MENG Juan^1,²,ZHAO Hai-yang^1,^2,^3,^*(

)

1 Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China
2 Biomedical Collaborative Innovation Center of Wenzhou, Wenzhou University, Wenzhou, Zhejiang 325035, China
3 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China

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Abstract

Lysosomal-autophagy system plays a critical part in the adaptive response of cells to nanomaterials. Autophagy has great utility in protecting cells from damage and keeping them stable. However, the essence of autophagy induced by nanomaterials is still unclear. Nanomaterials are recognized as alien invaders, the accumulation of which will activate the body's clearance mechanism. And this will lead to autophagy after the absorption of nanomaterials. This review introduces the self-protection mechanism of autophagy induced by nanomaterials, and analyzes the influence of nanomaterials on lysosomal-autophagy system and their biological effects comprehensively.

Key words： Autophagy Lysosomal Nanomaterials Liver injury

Received: 28 April 2019 Published: 15 January 2020

ZTFLH:

Q819

Corresponding Authors: Hai-yang ZHAO E-mail: haiyangwzu@163.com

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	Hui-lu ZHAN
	Ying BAI
	Yan ZHUANG
	Juan MENG
	Hai-yang ZHAO

Cite this article:

ZHAN Hui-lu,BAI Ying,ZHUANG Yan,MENG Juan,ZHAO Hai-yang. Research Progress of Autophagy Induced Protection by Nanomaterials. China Biotechnology, 2019, 39(12): 64-72.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20191209 OR https://manu60.magtech.com.cn/biotech/Y2019/V39/I12/64

Fig.1 Autophagy formation process and its molecular mechanism

Fig.2 Autophagy formation related signaling pathway


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