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| Advances in Studies on the Structure, Function and Related Antibodies of CD133 (Prominin-1) |
Yu-han CHENG,Xi GONG,Yu-ping LUO( ) |
| School of Life Sciences, Nanchang University, Nanchang 330031, China |
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Abstract CD133(Prominin-1) is one of members which are the five-time transmembrane glycoprotein Prominin family. CD133 was originally used as a specific marker for the screening of human hematopoietic stem and progenitor cells, which was subsequently used to isolate and identify specific cell subsets of various cancer stem cells. Many studies have shown that CD133 is a prognostic marker for tumor therapy, interacts with substances such as vascular endothelial growth factor, participates in signal transduction in cell pathways, and plays an important role in maintaining retinal morphology and function. Depending on whether or not it binds to a glycosylation epitope of CD133, antibodies related to CD133 can be classified into glycosylated antibodies, non-glycosylated antibodies, and other antibodies that are not indicated to bind to a glycosylated epitope. The recent years’ research of CD133 was focused,the Prominin family, and the functions, related antibodies and related research methods of CD133 were reviewed.
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Received: 08 October 2018
Published: 04 June 2019
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Corresponding Authors:
Yu-ping LUO
E-mail: luoyuping@163.com
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