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| Role of Signal Pathways and Related Factors Regulating Cartilage Formation in Bone Differentiation of Bone Marrow Mesenchymal Stem Cells |
ZHAO Jiu-mei,WANG Zhe( ),LI Xue-ying() |
| Medical Genetics Department of Zunyi Medical University, Zunyi 563099, China |
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Abstract Bone marrow mesenchymal stem cells are a type of adult stem cells with self-replication and multi-differentiation potential. It can differentiate into osteoblasts, chondrocytes, adipocytes, etc. through specific induction, so it has become the ideal seed cell for the most studies on bone regenerative medicine and cell therapy. Current studies have confirmed that in the process of bone marrow mesenchymal stem cells repairing bone defects, the expression increases of chondrogenesis-related genes in bone marrow mesenchymal stem cells, and then differentiate into chondrocytes. Later, with the formation of osteoblasts and osteoclasts and the growth of blood vessels, the cartilage matrix is gradually degraded and replaced by bone matrix. It shows that chondrocytes are involved in the pre-repair process of bone defects, and the signal pathways and related factors that regulate cartilage formation not only regulate the differentiation of bone marrow mesenchymal stem cells into chondrocytes, at the same time, they also play an important role in the process of osteoblast differentiation. Therefore, this article summarizes the regulatory effects and current research status of the signal pathways and related factors that regulate cartilage formation in the bone differentiation of bone marrow mesenchymal stem cells, in order to provide a theoretical basis and research direction for the clinical search for better treatment of bone defects.
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Received: 08 May 2021
Published: 08 November 2021
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Corresponding Authors:
Zhe WANG,Xue-ying LI
E-mail: fuzzywong@foxmail.com;leexueying4722@163.com
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