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| Advances in Research on Melanin Synthesis and Signaling Pathway in Fish |
WANG Tian-zhu,WU Qing,ZHANG Ning,WANG Dong-jie,XU Zhou,LUO Wei,DU Zong-jun( ) |
| College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China |
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Abstract Fish has been used as an important model for melanoma research. In recent years, great progress has been made in the study of fish melanin due to its melanoma model with uniform pathological characteristics and ease of reproduction. Melanocytes are the most important pigment cells in fish. The eumelanin has an important effect on the surface coloring and life activities of fish. The synthesis process mainly involves the catalytic action of the tyrosine gene family. Pheomelanin was previously thought to be non-existent in fish, but recent research has yielded different insights. With the extensive study of fish melanin synthesis, its synthetic regulation mechanism has also been studied in depth. In the signal pathway that regulates melanin synthesis, microphthalmia-associated transcription factor (Mitf) is a key regulator of various signaling pathways, which is affected by upstream α-Msh/Mc1r, Wnt/β-Catenin, and Scf/c-Kit and other signaling pathways mediate the downstream tyrosine gene family and regulate the synthesis of melanin. The synthesis of fish melanin and related signaling pathways be reviewed, with a view to providing a reference for the basic theory of fish melanin synthesis and aquaculture, and also to help understand the origin and regulation of human melanin synthesis, and to overcome melanoma.
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Received: 08 December 2019
Published: 02 June 2020
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Corresponding Authors:
Zong-jun DU
E-mail: 756662181@qq.com
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