合成生物学领域技术发展态势与研究进展<sup>*</sup>

doi:10.13523/j.cb.2310009

中国生物工程杂志

2024, Vol. 44

Issue (5): 118-133 DOI: 10.13523/j.cb.2310009

技术情报

合成生物学领域技术发展态势与研究进展^*

江洪^1,^2,^3,^**(

),李晓南^1,^2,³,高倩^1,³

1 中国科学院武汉文献情报中心武汉 430071
2 中国科学院大学经济与管理学院信息资源管理系北京 101408
3 科技大数据湖北省重点实验室武汉 430071

Technology Development Trend and Research Progress of Synthetic Biology

JIANG Hong^1,^2,^3,^**(

),LI Xiaonan^1,^2,³,GAO Qian^1,³

1 Wuhan Library,Chinese Academy of Sciences,Wuhan 430071, China
2 Department of Information Resources Management, School of Economics and Management, University of Chinese Academy of Sciences, Beijing 100190, China
3 Hubei Key Laboratory of Big Data in Science and Technology, Wuhan 430071, China

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摘要：

近年来,合成生物学因其所具有的革命式、颠覆式创新潜力,已经成为世界各国必争的科技战略高地,正在引发新一轮的科技与产业国际竞争。对比分析国内外合成生物学领域的专利发展态势,梳理全球合成生物学在元件工程、线路工程、代谢工程、基因组与细胞工程的基础研究前沿,并对合成生物学在医疗、食品、农业等领域的应用进行归纳。最后针对国家宏观支持、专利技术应用、基础研究发展三个方面提出对我国合成生物学进一步发展的启示与建议。

关键词： 合成生物学; 专利分析; 元件工程; 线路工程; 代谢工程; 基因组工程

Abstract:

In recent years, due to its revolutionary and disruptive innovation potential, synthetic biology has become a strategic highland for science and technology in all countries of the world, triggering a new round of international competition in science and technology and industry. This paper compares and analyzes the patent development trend in the field of synthetic biology at home and abroad, sorts out the basic research frontiers of global synthetic biology in synthetic biological parts engineering, circuit engineering, metabolic engineering, genome and cell engineering, and summarizes the application of synthetic biology in the fields of medicine, food, agriculture and other fields. Finally, it provides insights and suggestions for the further development of synthetic biology in China from the three aspects of national macro support, patent technology application, and basic research development.

Key words: Synthetic biology Patent analysis Synthetic biological parts engineerin Circuit engineering Metabolic engineering Genome

收稿日期: 2023-10-10 出版日期: 2024-06-05

ZTFLH:

Q819

基金资助: * 湖北省软科学研究重点项目(2023EDA019)

通讯作者: ** 电子信箱:jianghong@mail.whlib.ac.cn

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引用本文:

江洪, 李晓南, 高倩. 合成生物学领域技术发展态势与研究进展^*[J]. 中国生物工程杂志, 2024, 44(5): 118-133.

JIANG Hong, LI Xiaonan, GAO Qian. Technology Development Trend and Research Progress of Synthetic Biology. China Biotechnology, 2024, 44(5): 118-133.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2310009 或 https://manu60.magtech.com.cn/biotech/CN/Y2024/V44/I5/118

图1 2000年以来全球主要国家/地区合成生物学战略布局发展情况

图2 全球专利申请趋势对比

表1 全球合成生物学专利受理国和来源国矩阵

表2 全球合成生物学领域专利技术构成排名前十位

图3 全球合成生物学专利技术应用领域分布

表3 全球合成生物学领域代表专利权人

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