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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2022, Vol. 42 Issue (4): 78-84    DOI: 10.13523/j.cb.2110043
综述     
三维基因组学在动物遗传育种中的研究进展*
陈羿何1,李欣淼1,彭巍2,雷初朝1,赵黄青1,张子敬3,刘贤4,黄永震1,**()
1 西北农林科技大学动物科技学院 杨凌 712100
2 青海大学青海省畜牧兽医科学院 西宁 810016
3 河南省农业科学院畜牧兽医研究所 郑州 450002
4 河南省畜牧总站 郑州 450008
Research Progress of Three-dimensional Genomics in Animal Genetics and Breeding
CHEN Yi-he1,LI Xin-miao1,PENG Wei2,LEI Chu-zhao1,ZHAO Huang-qing1,ZHANG Zi-jing3,LIU Xian4,HUANG Yong-zhen1,**()
1 College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling 712100, China
2 Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China
3 Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
4 Henan Provincial Animal Husbandry General Station, Zhengzhou 450008, China
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摘要：

三维基因组学是近年兴起的研究基因组三维空间和结构的学科,是在基因组序列、基因结构及其调控元件的基础上对基因组序列在细胞核内的三维空间结构,及其对基因复制、转录、修复和调控等生物过程中的功能进行的研究。随着高通量测序技术的出现和改进,三维基因组学相关研究也得到快速发展。重点介绍三维基因组的发展历程、研究技术、结构层次,并总结近年来三维基因组学在动物遗传育种方面的应用。
关键词： 三维基因组;  染色质空间结构;  动物遗传育种    
Abstract:

Three-dimensional genomics is a newly developed subject that studies the three-dimensional space and structure of genome. Based on considering genome sequence, gene structure and its regulatory elements, it studies the functions of gene replication, transcription, repair and regulation in biological processes and the three-dimensional structure of genome sequence in the nucleus. With the emergence and improvement of high-throughput sequencing technology, the research of three-dimensional genomics has developed rapidly. This paper focuses on the development process, research technology and structural level of three-dimensional genomics, and summarizes the application of three-dimensional genomics in animal genetics and breeding in recent years.
Key words: Three-dimensional genome    Chromatin spatial structure    Animal genetics and breeding
收稿日期: 2021-10-27 出版日期: 2022-05-05
ZTFLH:  Q812  
基金资助: * 财政部和农业农村部国家现代农业产业技术体系(CARS-37);青海省科技计划(2021-ZJ-736);河南省肉牛产业技术体系(S2013-08)
通讯作者: 黄永震     E-mail: hyzsci@nwafu.edu.cn
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陈羿何
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黄永震

引用本文:

陈羿何,李欣淼,彭巍,雷初朝,赵黄青,张子敬,刘贤,黄永震. 三维基因组学在动物遗传育种中的研究进展*[J]. 中国生物工程杂志, 2022, 42(4): 78-84.

CHEN Yi-he,LI Xin-miao,PENG Wei,LEI Chu-zhao,ZHAO Huang-qing,ZHANG Zi-jing,LIU Xian,HUANG Yong-zhen. Research Progress of Three-dimensional Genomics in Animal Genetics and Breeding. China Biotechnology, 2022, 42(4): 78-84.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2110043    或    https://manu60.magtech.com.cn/biotech/CN/Y2022/V42/I4/78

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