纳米材料诱导自噬引发保护作用的研究进展

doi:10.13523/j.cb.20191209

中国生物工程杂志

2019, Vol. 39

Issue (12): 64-72 DOI: 10.13523/j.cb.20191209

综述

纳米材料诱导自噬引发保护作用的研究进展

詹蕙璐^1,^2,³,白莹^1,²,庄严^1,²,孟娟^1,²,赵海洋^1,^2,^3,^*(

)

1 温州大学生命科学研究院浙江温州 325035
2 温州市生物医药协同创新中心温州 325035
3 温州医科大学药学院温州 325035

Research Progress of Autophagy Induced Protection by Nanomaterials

ZHAN Hui-lu^1,^2,³,BAI Ying^1,²,ZHUANG Yan^1,²,MENG Juan^1,²,ZHAO Hai-yang^1,^2,^3,^*(

)

1 Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China
2 Biomedical Collaborative Innovation Center of Wenzhou, Wenzhou University, Wenzhou, Zhejiang 325035, China
3 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China

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摘要：

溶酶体-自噬系统在细胞对纳米材料的适应性反应中起到关键作用。自噬在保护细胞免受损伤和保持细胞稳定方面发挥重大作用,但纳米材料引起自噬的本质尚不清楚。纳米材料被细胞认为是外来入侵者,其积累将激活机体的清除机制,引发自噬。介绍了纳米材料诱导自噬发生的自我保护机制,综合分析了纳米材料对溶酶体-自噬系统的影响及其生物学效应。

关键词： 自噬; 溶酶体; 纳米材料; 肝损伤

Abstract:

Lysosomal-autophagy system plays a critical part in the adaptive response of cells to nanomaterials. Autophagy has great utility in protecting cells from damage and keeping them stable. However, the essence of autophagy induced by nanomaterials is still unclear. Nanomaterials are recognized as alien invaders, the accumulation of which will activate the body's clearance mechanism. And this will lead to autophagy after the absorption of nanomaterials. This review introduces the self-protection mechanism of autophagy induced by nanomaterials, and analyzes the influence of nanomaterials on lysosomal-autophagy system and their biological effects comprehensively.

Key words: Autophagy Lysosomal Nanomaterials Liver injury

收稿日期: 2019-04-28 出版日期: 2020-01-15

ZTFLH:

Q819

通讯作者: 赵海洋 E-mail: haiyangwzu@163.com

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引用本文:

詹蕙璐,白莹,庄严,孟娟,赵海洋. 纳米材料诱导自噬引发保护作用的研究进展[J]. 中国生物工程杂志, 2019, 39(12): 64-72.

ZHAN Hui-lu,BAI Ying,ZHUANG Yan,MENG Juan,ZHAO Hai-yang. Research Progress of Autophagy Induced Protection by Nanomaterials. China Biotechnology, 2019, 39(12): 64-72.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20191209 或 https://manu60.magtech.com.cn/biotech/CN/Y2019/V39/I12/64

图1 自噬形成过程及其分子机制

图2 自噬形成相关信号通路

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