细胞自噬是一种进化上高度保守的胞内降解系统,旨在实现维持细胞稳态以应对不同的细胞应激。在生理状态下,细胞自噬水平通常较低;而在氧化应激、营养饥饿和各种病原体刺激下会显著上调。过去的许多研究都表明细胞自噬在多种组织细胞和生理功能调控中有重要意义。早期研究发现了细胞自噬和中性粒细胞死亡之间的联系,这是与炎症密切关联的必要过程。在人类系统和小鼠模型中表明,细胞自噬在中性粒细胞驱动的炎症和防御病原体方面起着至关重要的作用。细胞自噬对中性粒细胞主要功能的发挥至关重要,包括脱颗粒、活性氧产生和中性粒细胞胞外诱捕网的释放。细胞自噬对中性粒细胞分化以及主要功能(包括脱颗粒、活性氧产生和中性粒细胞胞外诱捕网的释放)的发挥至关重要。集中讨论了细胞自噬对中性粒细胞的作用,即从中性粒细胞在骨髓中产生到炎症反应和NETosis细胞死亡。

Autophagy is an evolutionarily highly conserved intracellular degradation system designed to maintain cellular homeostasis in response to cellular stress. In physiological states, the level of autophagy is usually low; however, it is significantly upregulated under oxidative stress, nutritional starvation, and various pathogens. Many studies in the past have shown that autophagy plays an important role in the regulation of various histiocytes and physiological functions. Early studies have found a link between autophagy and neutrophil death, a necessary process closely related to inflammation. Autophagy plays a crucial role in neutrophil-driven inflammation and defense against pathogens in human and mouse models. Autophagy is essential for neutrophil differentiation and major functions, including degranulation, reactive oxygen species production, and release of neutrophil extracellular trapping nets. The role of autophagy in neutrophils, from neutrophils to inflammatory responses and NETosis cell death in the bone marrow were focused.