研究报告 |
|
|
|
|
帕比司他逆转前列腺癌细胞hepaCAM基因表达机制研究 |
陈娥1, 欧俐苹1, 唐敏1, 刘南京1, 吴小候2, 罗春丽1 |
1. 重庆医科大学检验医学院临床检验诊断学教育部重点实验室 重庆 400016;
2. 重庆医科大学附属第一医院 重庆 400016 |
|
The Mechanisms of Panobinostat Reversing HepaCAM Gene Expression in Prostate Cancer |
CHEN Er1, OU Li-ping1, TANG Min1, LIU Nan-jing1, WU Xiao-hou2, LUO Chun-li1 |
1. Key Laboratory of Clinical Laboratory Diagnostics of Ministry of Education, Faculty of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China;
2. Department of Urinary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China |
引用本文:
陈娥, 欧俐苹, 唐敏, 刘南京, 吴小候, 罗春丽. 帕比司他逆转前列腺癌细胞hepaCAM基因表达机制研究[J]. 中国生物工程杂志, 2016, 36(6): 9-17.
CHEN Er, OU Li-ping, TANG Min, LIU Nan-jing, WU Xiao-hou, LUO Chun-li. The Mechanisms of Panobinostat Reversing HepaCAM Gene Expression in Prostate Cancer. China Biotechnology, 2016, 36(6): 9-17.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20160602
或
https://manu60.magtech.com.cn/biotech/CN/Y2016/V36/I6/9
|
[1] Siegel R L, Miller K D, Jemal A. Cancer statistics, 2015. Cancer Journal for Clinicians, 2015, 65(1):5-29.
[2] 宋琳衍.我国前列腺癌的诊断与治疗最新近况.中国医药指南,2012,10(36):50-52. Song L Y. The latest status of the diagnosis and treatment of prostate cancer. Guide of China Medicine,2012,10(36):50-52.
[3] Heidenreich A, Aus G, Bolla M, et al. EAU guidelines on prostate cancer. Eur Urol, 2008, 53(1):68-80.
[4] Moh M C,Lee L H,Shen S, et al. Coloning and characterization of hepaCAM,a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma.J Hepatol,2005,42(6):833-841.
[5] Song X, Wang Y, Du H, et al. Overexpression of HepaCAM inhibits cell viability and motility through suppressing nucleus translocation of androgen receptor and ERK signaling in prostate cancer. The Prostate, 2014, 74(10):1023-1033.
[6] Cheng T, Grasse L, Shah J, et al. Panobinostat, a pan-histone deacetylase inhibitor: rationale for and application to treatment of multiple myeloma. Drugs of Today, 2015, 51(8):491-504.
[7] Tessarz P, Santos-Rosa H, Robson S C, et al. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature, 2014, 505(7484):564-568.
[8] 王晓荣,杨雪,王胤,等. 5-氮杂胞嘧啶核苷联合hepaCAM腺病毒通过抑制p-AKT诱导膀胱癌细胞T24凋亡. 重庆医科大学学报,2014,39(06):762-767. Wang X R, Yang X, Wang Y, et al. Inducing apoptosis of bladder cancer cell T24 by 5-azacytidine combined with adenovirus-hepaCAM via inhibiting p-AKT. Journal of Chongqing Medical University,2014,39(06):762-767.
[9] Wang Q, Luo C, Wu X, et al. hepaCAM and p-mTOR closely correlate in bladder transitional cell carcinoma and hepaCAM expression inhibits proliferation via an AMPK/mTOR dependent pathway in human bladder cancer cells. The Journal of Urology,2013,190(5):1912-1918.
[10] Jiang X L, Zhang Y, Tan B, et al. Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a p-AKT-dependent manner. Neoplasma, 2014,61(4):416-423.
[11] Pan C, Wu X, Luo C, et al. Exon 2 methylation inhibits hepaCAM expression in transitional cell carcinoma of the bladder. Urologia Internationalis, 2010, 85(3):347-354.
[12] Tao J, Liu Q, Wu X, et al. Identification of hypermethylation in hepatocyte cell adhesion molecule gene promoter region in bladder carcinoma. International Journal of Medical Sciences, 2013, 10(13):1860-1867.
[13] Dawson M A, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell, 2012, 150(1):12-27.
[14] Seiler R, Thalmann G N, Rotzer D, et al. CCND1/CyclinD1 status in metastasizing bladder cancer: a prognosticator and predictor of chemotherapeutic response. Modern Pathology, 2014, 27(1):87-95.
[15] Nguyen H D, Bielinsky A K. HDM2 ERKs PCNA. The Journal of Cell Biology, 2010,190(4):487-489. |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|