成纤维细胞生长因子5的研究进展 <sup>*</sup>

doi:10.13523/j.cb.1905012

中国生物工程杂志

2020, Vol. 40

Issue (3): 117-124 DOI: 10.13523/j.cb.1905012

综述

成纤维细胞生长因子5的研究进展 ^*

杨丹¹,田海山²,李校堃^1,^2,^**(

)

1 温州大学生命与环境科学学院温州 325035
2 温州医科大学药学院温州 325035

Research Progress of Fibroblast Growth Factor 5

YANG Dan¹,TIAN Hai-shan²,LI Xiao-kun^1,^2,^**(

)

1 College of life and Environmental Science, Wenzhou University, Wenzhou 325035, China
2 School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China

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摘要：

成纤维细胞生长因子5(fibroblast growth factor 5,FGF5)是成纤维细胞生长因子家族(FGFs)的成员之一,在哺乳动物毛囊,神经系统,睾丸等多个部位及胚胎发育过程中均有表达.研究发现,FGF5具有广泛的生物学活性,如作为毛发生长重要的调节因子其编码基因突变将导致毛发异常生长,作为丝裂原在干细胞增殖,血管生成和肢体肌发育等方面发挥重要作用,以及在高血压,肿瘤等方面具有重要的生物学功能.目前,FGF5在多种疾病中的功能和作用机制尚需进一步深入研究,但其在毛发生长,干细胞增殖及在心血管疾病等方面的生物学作用具有重大的意义和临床应用价值.总结了近些年FGF5的研究进展,系统阐述了FGF5在毛发生长,干细胞增殖分化,心血管疾病及癌症等方面的相关作用机制,为进一步深入研究FGF5在疾病治疗中的作用和开发利用提供参考.

关键词： 成纤维细胞生长因子5; 毛发生长; 干细胞增殖; 心血管疾病

Abstract:

Fibroblast growth factor 5 (FGF5) is a member of the fibroblast growth factor family (FGFs) and is expressed in mammalian hair follicles, nervous system, testis and other parts of the embryo and during embryonic development. The study found that FGF5 has a wide range of biological activities, such as an important regulator of hair growth, its genetic mutation will lead to abnormal hair growth; as a mitogen plays an important role in stem cell proliferation, angiogenesis and limb muscle development; It has important biological functions in hypertension and tumors. At present, the function and mechanism of action of FGF5 in various diseases need further study, but its biological effects in hair growth, stem cell proliferation and cardiovascular diseases have great significance and clinical application value. The research progress of FGF5 in recent years, systematically expounds the related mechanism of FGF5 in hair growth, stem cell proliferation and differentiation, cardiovascular disease and cancer, and provides further research on the role and development of FGF5 in disease treatment were summarized.

Key words: FGF5 Hair growth Stem cell proliferation Cardiovascular disease

收稿日期: 2019-05-09 出版日期: 2020-04-18

ZTFLH:

Q819

基金资助: * 浙江省药学重中之重一级学科开放基金(201722)

通讯作者: 李校堃 E-mail: profxiaokunli@163.com

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引用本文:

杨丹,田海山,李校堃. 成纤维细胞生长因子5的研究进展 ^*[J]. 中国生物工程杂志, 2020, 40(3): 117-124.

YANG Dan,TIAN Hai-shan,LI Xiao-kun. Research Progress of Fibroblast Growth Factor 5. China Biotechnology, 2020, 40(3): 117-124.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.1905012 或 https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I3/117

图1 人类FGF5和FGF5s氨基酸序列

毛囊周期		毛囊形态特征
静止期	静止期	毛囊被真皮成纤维细胞包围,无明显的内根鞘,球形状的毛乳头附着在次生毛胚角质形成细胞上,毛囊长度达到最短
生长期	生长期I和II	毛乳头和杵状毛之间的角质形成细胞增厚和延长,生长期II毛乳头增大,形成了毛囊球部,毛囊球部和毛乳头位于真皮和皮下组织之间
	生长期III	毛囊球部围绕着毛乳头,形成成熟的内根鞘,外根鞘和内根鞘区分明显.黑色素生成并充分发育,毛干变色.毛囊球部达到最大,毛乳头和毛囊球部到达最深的位置并停留在肉膜附近
	生长期IV和V	毛乳头变窄,毛乳头直径小于毛囊球部,生长期IV期间,毛干和内根鞘到达了毛管,在生长期V时新形成的毛干进入毛管但仍然被内根鞘封闭
	生长期VI	当毛干的尖端通过表皮露出皮肤时,生长期VI便开始了,毛乳头变得狭窄细长.此时毛囊长度达到最大
退行期	退行期I和II	退行期I和生长期VI很难区分,退行期II毛囊的长度变化不明显,但毛囊球部变小,毛乳头更加狭窄
	退行期III	毛乳头变成洋葱状,这是其他任何阶段都没有的特征.毛囊球部变小
	退行期IV	毛囊长度缩短,毛乳头形状呈球形,毛囊球部缩回,只有发干远端有色素
	退行期V	皮肤整体厚度和毛囊长度大大减少,杵状毛发育,形成了第二个胚芽囊,导致毛乳头和胚芽囊之间的上皮细胞链收缩.内根鞘变得不透明但显示出了清晰的边界
	退行期VI	杵状毛底部呈刷状,并开始向远端移动.不透明的内根鞘和外根鞘的界限明显
	退行期VII	毛乳头向上运动,留下了结缔组织鞘长尾巴,位于皮下组织中间
	退行期VIII	毛囊长度明显短于退行期VII,毛乳头位于真皮和皮下组织之间,内根鞘的残余物存在于皮脂腺层面.

表1 毛囊各个时期形态特征

图2 毛囊循环关键阶段的示意图

表2 FGFs在毛发生长周期中的分布

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