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Advances in Genetically Engineered Animal Models of Chronic Obstructive Pulmonary Disease |
LIU Di1,2,ZHANG Hong-chun2,**() |
1 Beijing University of Chinese Medicine, Beijing 100029, China 2 Department of TCM Pulmonary Diseases, China-Japan Friendship Hospital; Center of Respiratory Medicine, China-Japan Friendship Hospital; National Clinical Research Center for Respiratory Diseases, Beijing 100029, China |
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Abstract Chronic obstructive pulmonary disease (COPD) is a common chronic airway inflammatory disease with high morbidity and mortality in China, and it has caused heavy social and economic burden. It is reported that the incidence of COPD is closely related to genetic and environmental factors. Animal model is an important tool to study its pathogenesis, prevention, treatment and identify potential therapeutic targets and biomarkers. With the development of genetic engineering technology and the continuous discovery of related targets and genes of COPD, gene modified animal models are increasingly established and used in COPD research. In this paper, we searched published papers in PubMed to analyze the animal species and modeling methods of previous models of COPD. Then we data-mined the susceptibility genes of COPD and reviewed the susceptibility genes of different species by literature and database tool analysis. Finally, we integrated and listed the information and research progress of COPD genetic engineering mouse and rat models. Those informations are convenient for researchers and clinicians to reference and use. Thereafter, they can facilitate the research of pathogenesis and prevention methods of COPD.
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Received: 03 October 2019
Published: 18 May 2020
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Corresponding Authors:
Hong-chun ZHANG
E-mail: 13701226664@139.com
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[1] |
Vos T, Allen C, Arora M , et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet, 2016,388(10053):1545-1602.
doi: 10.1016/S0140-6736(16)31678-6
pmid: 27733282
|
|
|
[2] |
Wang C, Xu J, Yang L , et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. The Lancet, 2018,391(10131):1706-1717.
doi: 10.1016/S0140-6736(18)30841-9
pmid: 29650248
|
|
|
[3] |
Zeng G, Sun B, Zhong N . Non-smoking-related chronic obstructive pulmonary disease: a neglected entity? Respirology, 2012,17(6):908-912.
doi: 10.1111/j.1440-1843.2012.02152.x
pmid: 22845669
|
|
|
[4] |
Yohan B . Genetics of chronic obstructive pulmonary disease: a succinct review, future avenues and prospective clinical applications. Pharmacogenomics, 2009,10(4):655-667.
doi: 10.2217/pgs.09.10
pmid: 19374520
|
|
|
[5] |
樊林花, 刘茂林, 刘田福 . 人类疾病基因工程动物模型的研究与应用. 医学综述, 2009,15(07):1009-1012.
|
|
|
[5] |
Fan L H, Liu M L, Liu T F . Research and application of genetic engineering animal models for human diseases. Medical Review, 2009,15(07):1009-1012.
|
|
|
[6] |
Francesca P, Melanie D-E, Jacob M , et al. A novel nonhuman primate model of cigarette smoke-induced airway disease. The American Journal of Pathology, 2015,185(3):741-755.
doi: 10.1016/j.ajpath.2014.11.006
pmid: 25542772
|
|
|
[7] |
J N K, H G F . Animal models of chronic bronchitis and their relevance to studies of particle-induced disease. Inhalation Toxicology, 2000,12 Suppl 4: 123-153.
doi: 10.1080/089583700750019549
pmid: 12881890
|
|
|
[8] |
Mestas J, Hughes C C . Of mice and not men: differences between mouse and human immunology. J Immunol, 2004,172(5):2731-2738.
doi: 10.4049/jimmunol.172.5.2731
pmid: 14978070
|
|
|
[9] |
Chen L, Yuan X, Zou L , et al. Effects of 1,25-dihydroxyvitamin D3 on the prevention of chronic obstructive pulmonary disease (COPD) in rats exposed to air pollutant particles less than 2.5 micrometers in diameter (PM2.5). Med Sci Monit, 2018,24:356-362.
doi: 10.12659/msm.905509
pmid: 29345249
|
|
|
[10] |
Ramirez-Ramirez E, Torres-Ramirez A, Alquiciar-Mireles J , et al. Characteristic plethysmographic findings in a guinea pig model of COPD. Exp Lung Res, 2017,43(2):57-65.
doi: 10.1080/01902148.2017.1294632
pmid: 28318340
|
|
|
[11] |
刘翱, 邹雷, 李少莹 , 等. 阻塞性肺气肿模型的制作. 中国比较医学杂志, 2008(02):15-18.
|
|
|
[11] |
Liu A, Zou L, Li S Y , et al. Making of the model of obstructive emphysema. Chinese Journal of Comparative Medicine, 2008(02):15-18.
|
|
|
[12] |
G P C, M H D . The non-human primate as a model for studying COPD and asthma. Pulmonary Pharmacology and Therapeutics, 2008,21(5):755-766.
doi: 10.1016/j.pupt.2008.01.008
pmid: 18339566
|
|
|
[13] |
宋小莲, 王昌惠, 白冲 . 脂多糖结合熏烟法和单纯熏烟法建立慢性阻塞性肺病大鼠模型的比较. 第二军医大学学报, 2010,31(03):246-249.
|
|
|
[13] |
Song X L, Wang C H, Bai C . Lipopolysaccharide combined with smoking and smoking alone to establish a rat model of chronic obstructive pulmonary disease. Journal of Second Military Medical University, 2010,31(03):246-249.
|
|
|
[14] |
Hobbs B D, De Jong K, Lamontagne M , et al. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet, 2017,49(3):426-432.
doi: 10.1038/ng.3752
pmid: 28166215
|
|
|
[15] |
Faiz A, Van Den Berge M, Vermeulen C J , et al. AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers. Respir Res, 2019,20(1):70.
doi: 10.1186/s12931-019-1038-6
pmid: 30971245
|
|
|
[16] |
Maltais F, Gaudreault N, Racine C , et al. Clinical experience with SERPINA1 DNA sequencing to detect alpha-1 antitrypsin deficiency. Ann Am Thorac Soc, 2018,15(2):266-268.
doi: 10.1513/AnnalsATS.201708-694RL
pmid: 29182883
|
|
|
[17] |
Cho M H, Mcdonald M L, Zhou X , et al. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med, 2014,2(3):214-225.
doi: 10.1016/S2213-2600(14)70002-5
pmid: 24621683
|
|
|
[18] |
Kheirallah A K, De Moor C H, Faiz A , et al. Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways. BMC Genomics, 2017,18(1):248.
doi: 10.1186/s12864-017-3628-3
pmid: 28335732
|
|
|
[19] |
Soler Artigas M, Loth D W, Wain L V , et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet, 2011,43(11):1082-1090.
doi: 10.1038/ng.941
pmid: 21946350
|
|
|
[20] |
Panvert M, Dubiez E, Arnold L , et al. Cdc123, a cell cycle regulator needed for eIF2 assembly, is an ATP-grasp protein with unique features. Structure, 2015,23(9):1596-1608.
doi: 10.1016/j.str.2015.06.014
pmid: 26211610
|
|
|
[21] |
Fjorder A S, Rasmussen M B, Mehrjouy M M , et al. Haploinsufficiency of ARHGAP42 is associated with hypertension. Eur J Hum Genet, 2019,27(8):1296-1303.
doi: 10.1038/s41431-019-0382-9
pmid: 30903111
|
|
|
[22] |
Hu Q, Lin X, Ding L , et al. ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma. Cancer Med, 2018,7(8):3862-3874.
doi: 10.1002/cam4.1552
pmid: 29936709
|
|
|
[23] |
Prokopenko D, Sakornsakolpat P, Fier H L , et al. Whole-genome sequencing in severe chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 2018,59(5):614-622.
doi: 10.1165/rcmb.2018-0088OC
pmid: 29949718
|
|
|
[24] |
杨玉琪, 赵远 . 人类疾病的转基因动物模型研究概述. 中国比较医学杂志, 2005(03):170-173.
|
|
|
[24] |
Yang Y Q, Zhao Y . An overview of the research on genetically modified animal models of human diseases. Chinese Journal of Comparative Medicine, 2005(03):170-173.
|
|
|
[25] |
Sundar I K, Yin Q, Baier B S , et al. DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. Clin Epigenetics, 2017(9):38.
doi: 10.1186/s13148-017-0335-5
pmid: 28416970
|
|
|
[26] |
Jungang X, Hibgxu W, Yuzhu X , et al. Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline. Respiratory Research, 2015(16):49.
doi: 10.1186/s12931-015-0209-3
pmid: 25928290
|
|
|
[27] |
S W E, Yan L, Taotao L , et al. Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease. Scientific Reports, 2017,7(1):2504.
doi: 10.1038/s41598-017-02701-4
pmid: 28566717
|
|
|
[28] |
Zhiqiang J, Taotao L, Weiliang Q , et al. A chronic obstructive pulmonary disease susceptibility gene, FAM13A, regulates protein stability of β-catenin. American Journal of Respiratory and Critical Care Medicine, 2016,194(2):185-197.
doi: 10.1164/rccm.201505-0999OC
pmid: 26862784
|
|
|
[29] |
S P N, R B K, Tania M , et al. The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease. Experimental Lung Research, 2010,36(8):469-483.
doi: 10.3109/01902141003739723
pmid: 20939756
|
|
|
[30] |
Eurlings I M, Dentener M A, Mercken E M , et al. A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-alpha. Am J Physiol Lung Cell Mol Physiol, 2014,307(7):L557-565.
doi: 10.1152/ajplung.00116.2014
pmid: 25106431
|
|
|
[31] |
P H C, K S E, Jody G , et al. SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development. American Journal of Respiratory and Critical Care Medicine, 2011,183(11):1428-1429.
doi: 10.1164/rccm.201603-0579LE
pmid: 27905851
|
|
|
[32] |
Roos A B, Sethi S, Nikota J , et al. IL-17A and the promotion of neutrophilia in acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2015,192(4):428-437.
doi: 10.1164/rccm.201409-1689OC
pmid: 26039632
|
|
|
[33] |
Shapiro S D . Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease. The European Respiratory Journal, 2007,29(2):375-378.
doi: 10.1183/09031936.00087606
pmid: 17264324
|
|
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