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中国生物工程杂志

China Biotechnology
China Biotechnology  2017, Vol. 37 Issue (5): 87-96    DOI: 10.13523/j.cb.20170511
    
Advance in Research on Antibody Half-Life Related Engineering
CHEN Jing1, KANG Ci-ming1, LUO Wen-xin1,2
1. National Institute of Diagnostics Vaccine Developmentin Infectious Disease, School of Life Sciences, Xiamen University, Xiamen 361102, China;
2. School of Public Health, Xiamen University, Xiamen 361102, China
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Abstract  

Withthe growing development of therapeutic monoclonal antibodies in the clinical treatment, the market share and research cost of antibody drugs are increasing by years. In addition to the novel antibody drug development, the antibody engineering on efficacy and safety has been more strongly desired.Among theseengineering technologies, antibody half-life related engineeringhas been popularly used in improving antibody pharmacokinetic properties in recent years. Several kinds of antibody half-life modification methods are briefly described, as well as to their current status in clinical research.



Key wordsTherapeutic antibody      Half-life of antibody      Genetic engineering     
Received: 20 November 2016      Published: 25 May 2017
ZTFLH:  Q78  
Cite this article:

CHEN Jing, KANG Ci-ming, LUO Wen-xin. Advance in Research on Antibody Half-Life Related Engineering. China Biotechnology, 2017, 37(5): 87-96.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20170511     OR     https://manu60.magtech.com.cn/biotech/Y2017/V37/I5/87

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