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The Status Quo and Development Trend of the Therapeutic Monoclonal Antibody Drugs |
WANG Zhi-ming, GAO Jian, LI Geng |
NCPC New Drug Research and Development Co., Ltd.State Key Laboratory of Antibody Drug Development, Shijiazhuang 050015, China |
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Abstract After more than 30 years of development, monoclonal antibodies have become an important class of clinical drugs. Currently, these antibody drugs are used to treat many kinds of diseases, such as cancer, autoimmune diseases, infectious diseases and transplant rejection reactions. Ended in 2012, there are 29 kinds of therapeutic monoclonal antibody drugs through the FDA approval and on sale. And in 2011, there were more than 1000 kinds of antibody drugs undergoing clinical trials in the European Union or the United States, of which about 164 kinds of antibodies in clinical phase III trials. The safety and efficacy of therapeutic monoclonal antibody drug is largely decided by the target. Some monoclonal antibody drugs in research have the same targets with the antibodies on sale, and some have the unique targets. At the same time, more and more new targets are being found. There are four kinds of the most popular targets of research: tumor necrosis factor-α, cluster of differentiation 20, epidermal growth factor receptor and vascular endothelial growth factor. Detailed review which focuses on the different targets of the monoclonal antibody drugs, whether in research or on sale, is expected to provide valuable references for the monoclonal antibody drug development trend. The status quo of monoclonal antibody drug in our country was discussed, and the development strategies in the future were proposed.
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Received: 04 March 2013
Published: 25 June 2013
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