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中国生物工程杂志

China Biotechnology
China Biotechnology  2016, Vol. 36 Issue (9): 54-58    DOI: 10.13523/j.cb.20160907
    
Progression of Central Nervous System Disease Therapeutic Antibody Drug Application
REN Hua-jing, LIU Xiao-zhi, WANG Zhi-ming, GAO Jian
State Key Laboratory of Antibody Research & Development, New Drug Research and Development Company Ltd., North China Pharmaceutical Corporation, Shijiazhuang 050015, China
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Abstract  

Monoclonal antibody drugs is a new drug with high selectivity, was used for the treatment of various diseases, such as cancer, autoimmune diseases, can also be used for central nervous system diseases, such as Alzheimer's disease, Parkinson, stroke and brain tumors. However, because of the low permeability of the blood-brain barrier, limiting the application of antibody drugs in the treatment of central nervous system diseases, in many nervous system diseases clinical trials, antibody drugs did not achieve the desired results. Nowadays, people use the endogenous transporter in blood-brain barrier, designed new antibody drugs. The progression of central nervous system disease therapeutic antibody drug development, and the application prospects are reviewed.



Key wordsMonoclonal antibody drugs      Central nervous system diseases      Blood brain barrier     
Received: 29 February 2016      Published: 16 March 2016
ZTFLH:  Q816  
Cite this article:

REN Hua-jing, LIU Xiao-zhi, WANG Zhi-ming, GAO Jian. Progression of Central Nervous System Disease Therapeutic Antibody Drug Application. China Biotechnology, 2016, 36(9): 54-58.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20160907     OR     https://manu60.magtech.com.cn/biotech/Y2016/V36/I9/54

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