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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2017, Vol. 37 Issue (12): 103-110    DOI: 10.13523/j.cb.20171215
综述     
嗜酸菌耐酸pH平衡机制及潜在应用 *
张月明,乔建军()
天津大学化工学院制药工程系 系统生物工程教育部重点实验室 天津化学化工协同创新中心合成生物学平台 天津 300072
Mechanism of Acid Tolerance in Acidophiles with pH Homeostasis and Its Potential Applications
Yue-ming ZHANG,Jian-jun QIAO()
Syn Bio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China
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摘要：

嗜酸菌是一类可以在极端酸性环境下生存的微生物,在生物整治以及耐热耐酸酶的提取等领域发挥着重要作用。一些嗜中性工程菌株在发酵过程中经常遇到自身环境酸化的问题,嗜酸菌独特的耐酸能力及其耐酸模块为构建耐酸能力强的嗜中性工程菌株提供了思路。因此,从细胞膜的稳定性及低渗透性,耐酸相关的能量代谢,生物大分子的修复以及胞内缓冲作用等方面对嗜酸菌的耐酸机制进行深入探讨,并展望了嗜酸菌在耐酸工程菌株合成生物学领域的作用。
关键词： 嗜酸菌;  耐酸模块;  pH平衡机制;  合成生物学    
Abstract:

Acidophiles can survive in the extremely acidic environment and are most widely distributed in the bacterial and archaeal domains. They play an important role in the bioremediation and source of thermostable and acid-tolerant enzyme. Some neutral engineering strains often encountered the problem of acidification in the process of fermentation. Considering unique acid-tolerant ability of the acidophiles, if the acid-tolerant module from the acidophiles can get and applied to the neutral engineering strains, perhaps the acid-tolerant engineering strains could be built. Therefore, the common mechanisms for acid tolerance in acidophiles, including cell membrane stability and low permeability, energetic metabolism with acid tolerance, repair or protection of macromolecules and cytoplasmic buffering were overviewed, with a view to make some contributions for synthetic biology of acid-tolerant engineering strains.
Key words: Acidophiles    Acid-tolerant module    pH homeostasis    Synthetic biology
收稿日期: 2017-08-25 出版日期: 2017-12-16
ZTFLH:  Q819  
基金资助: 国家自然科学基金资助项目(31570089)
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引用本文:

张月明,乔建军. 嗜酸菌耐酸pH平衡机制及潜在应用 *[J]. 中国生物工程杂志, 2017, 37(12): 103-110.

Yue-ming ZHANG,Jian-jun QIAO. Mechanism of Acid Tolerance in Acidophiles with pH Homeostasis and Its Potential Applications. China Biotechnology, 2017, 37(12): 103-110.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20171215    或    https://manu60.magtech.com.cn/biotech/CN/Y2017/V37/I12/103

图1  嗜酸菌耐酸pH平衡机制
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