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| Advances in Quorum-sensing Bidirectional Interactions Between Phages and Bacteria |
Shuyang SUN1,Shengbo WU1,2,Xinqiao ZHANG1,Changchang LIANG1,Jianjun QIAO1,2,3,4,***( ) |
1 School of Chemical Engineering, Tianjin University, Tianjin 300072, China
2 Zhejiang Institute of Tianjin University (Shaoxing), Shaoxing 312300, China
3 Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China
4 Synthetic Biology Research Platform, Tianjin Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China |
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Abstract During the extensive co-evolutionary process, complex interactions have emerged between phages and bacterial hosts. Quorum sensing (QS) mechanisms play a prominent role in governing the interactions between phages and bacteria. This article begins by elucidating the exploitation of QS mechanisms by bacterial hosts, providing an overview of their consequential impacts on biofilm regulation, phage adsorption processes, and the modulation of the CRISPR-Cas system. Furthermore, the involvement of phages in QS mechanisms is expounded upon, encompassing a comprehensive survey of their role in phage lytic-lysogenic regulations and the suppression of QS mechanisms. Finally, this article presents a prospective investigation and explanation of phage QS mechanisms, aiming to provide a theoretical foundation for the application of QS mechanisms in the field of phage therapy and related areas.
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Received: 02 July 2023
Published: 04 February 2024
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