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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2024, Vol. 44 Issue (1): 118-127    DOI: 10.13523/j.cb.2307024
    
Research Progress of Microbial Quorum Sensing in Wastewater Biological Treatment
Qian WANG1,2,**(),Yixuan QIN1,Qiang KONG1,2,Huiyu LI1,Kejin ZONG1,Yinghui WANG1,Minghui RONG1
1 School of Geography and Environment of Shandong Normal University, Jinan 250358, China
2 Dongying Research Institute of Shandong Normal University, Dongying 257343, China
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Abstract  

Quorum sensing(QS), known as the language of intercellular communication is a gene regulatory system that relies on colony density. It is found in many natural and wastewater treatment engineering systems and plays an important role in environmental remediation and wastewater biotreatment.At present,there is a lack of systematic summary of the research methods and related applications of QS regulating bacterial function.In this paper,the QS mechanism mediated by three types of typical signal molecules(N-Acyl homoserine 1actones,autoinducing peptides and furanosyl borate diEnvironmental Science & Technologyer)of bacteria was summarized.The three techniques of adding or quenching signal molecules,genetic manipulation of genes,and omics techniques to study the function of the QS system were reviewed,and their advantages and disadvantages were compared and analyzed.The application of QS in activated sludge,biofilm and biological nitrogen removal in the field of industrial wastewater biological treatment was discussed.Finally,combined with the current application potential of QS cross-border communication in wastewater treatment and the limitations of known research contents,some studies on QS system-mediated bacterial-plant,bacterial-phage,bacterial-fungal cross-border communication mechanisms were discussed,in order to provide new ideas for using QS regulation strategies to enhance wastewater treatment efficiency in the future.

Key words： Wastewater biological treatment      Bacteria      Quorum sensing      Signal molecule     
Received: 17 July 2023      Published: 04 February 2024
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Qian WANG
Yixuan QIN
Qiang KONG
Huiyu LI
Kejin ZONG
Yinghui WANG
Minghui RONG
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Qian WANG, Yixuan QIN, Qiang KONG, Huiyu LI, Kejin ZONG, Yinghui WANG, Minghui RONG. Research Progress of Microbial Quorum Sensing in Wastewater Biological Treatment. China Biotechnology, 2024, 44(1): 118-127.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2307024     OR     https://manu60.magtech.com.cn/biotech/Y2024/V44/I1/118

Fig.1 Molecular structure of AHL
Fig.2 Typical AHL-QS system (A) and AIP-QS system (B)
Fig.3 QS system mediated by AI-1 and AI-2 in Vibrio harveyi The Q in the diagram indicates that the signal is transmitted through phosphorylation, and H and D represent histidine and aspartic acid, respectively, as phosphorylated residues of the signal transduction protein
应用领域 外源添加物名称 外源添加
物类型		 QS的促
进(+)
/抑制
(-)		 应用效果 参考文献
活性污泥 香草醛(vanillin) QSI - 香草醛减弱QS-AHL系统,延缓或抑制EPS中蛋白(PN)的产生,显著抑制丝状膨胀 [51]
C12-HSL、C14-HSL AHL + 抑制青霉菌菌丝体形成,缓解真菌性污泥膨胀,沉降能力分别提高了6.1%(C12-HSL)和39.7%(C14-HSL) [52]
C6-HSL AHL + 促进AGS快速粒化,提高AGS系统稳定性以及脱氮除磷性能 [55]
AGS中分离的
AHLs上清液		 QS菌 + AGS沉降性能优异(SVI10 37.2 mL/g),加速成粒(颗粒完整性系数为4.4%) [56]
生物膜 C6-HSL、3OC12-HSL AHL + 提高BESs电子摄取量(1.3~2.0倍)和反硝化速率(大于1.0倍),加速阴极生物膜的形成和启动 [57]
D-酪氨酸 QSI - 减少22%生物附着量,抑制活性污泥生物膜污染 [58]
Rhodococcus sp. BH4 QQ菌 - 减少MFC阳极微生物EPS的产生,缓解膜污染,维持良好电化学活性(1 924 mW/m2) [59]
Acinetobacter、Comamonas、
Stenotrophomonas		 QQ菌 - 大幅缓解AnMBR膜污染,将膜过滤时间延长3.72倍(P≤ 0.05) [60]
酰化酶 QQ酶 - 生物膜的黏附强度至少降低37%,生物膜厚度由1 562 μm减少到1 765 μm [61]
生物脱氮 C12-HSL AHL + 明显强化好氧氨氧化过程,导致亚氮积累 [62]
C12-HSL AHL + 显著增加氧限制自养硝化/反硝化生物膜中的厌氧氨氧化速率(P< 0.05) [63]
C14-HSL、3-oxo-C14-HSL、
C6-HSL、3-oxo-C6-HSL		 AHL + 处理16 d后,活性污泥氨氧化率提高了73% [64]
3-oxo-C6-HSL、
C6-HSL、C8-HSL		 AHL + 显著提高SBR(P< 0.05)第二阶段运行期间的脱氮率(NRR) [50]
硼 活化剂 + 刺激微生物自分泌AI-2,促进AOB并抑制NOB,造成N O 2 -累积,促进厌氧氨氧化,进而提高脱氮效率 [67]
蛭形轮虫 微型动物 + 分泌AHLs信号分子类似物,触发QS提高活性污泥对COD、氨氮、总磷的去除率 [68]
Table 1 Application of quorum sensing in wastewater biological treatment
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