Research Progresses on Quorum Sensing System Involved in Gram Positive Bacteria

doi:10.13523/j.cb.2208031

China Biotechnology

2023, Vol. 43

Issue (2/3): 165-173 DOI: 10.13523/j.cb.2208031

Research Progresses on Quorum Sensing System Involved in Gram Positive Bacteria

HU Xiu-ling,XIONG Li-yang,WEI Yun-lin^*(

)

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China

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Abstract

Quorum sensing system was not just involved in interbacterial communication but also involved in communication between bacteria and their hosts. It has been demonstrated that the difference in quorum sensing system invoved in gram positive and gram negative bacteria was statistically significan. The quorum sensing system of positive bacteria has played important roles in many of the physiological characteristics such as pathogenicity, which was composed of oligopeptide signal molecules and receptor proteins. In this paper the current research status and advances in gene composition, signal molecular characteristics and regulation mechanisms of quorum sensing system involved in typical gram-positive bacteria, such as Bacillus cereus, Bacillus subtilis, Staphylococcus aureus and Streptococcus pneumoniae were summarized. The regulatory mechanisms of quorum sensing system invovled in important physiological activities of bacteria, such as nutrient absorption, biofilm formation, virulence factor production, spore production and cytidine production were illustrated. This study will provide a reference for the future research on quorum sensing of gram-positive bacteria.

Key words： Gram-positive bacteria Quorum sensing system Signal molecule Gene regulation Infection mechanism

Received: 25 August 2022 Published: 31 March 2023

ZTFLH:

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Corresponding Authors: *Yun-lin WEI E-mail: homework18@126.com

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Cite this article:

HU Xiu-ling, XIONG Li-yang, WEI Yun-lin. Research Progresses on Quorum Sensing System Involved in Gram Positive Bacteria. China Biotechnology, 2023, 43(2/3): 165-173.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2208031 OR https://manu60.magtech.com.cn/biotech/Y2023/V43/I2/3/165

Fig.1 Three types of gene expression regulated by quorum sensing system (a) Gram-negative (b) Gram-positive (c) luxS/AI-2

Fig.2 The mechanisms of quorum sensing systems involved in gram-positive bacteria

Table 1 Quorum sensing system and related phenotypes of some gram-positive bacteria

Fig.3 The illustration demonstrates the PlcR-PaPR QS circuit in B. cereus

Fig. 4 The illustration demonstrates the ComQXPA QS circuit in B. subtilis

Fig.5 The illustration demonstrates the Agr QS circuit in S. aureus

Fig.6 The illustration demonstrates the ComABCDE QS circuit in S. pneumoniae


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