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中国生物工程杂志

China Biotechnology
China Biotechnology  2022, Vol. 42 Issue (5): 139-145    DOI: 10.13523/j.cb.2203050
    
Status Analysis and Suggestions of Collecting Human Genetic Resources in China
ZHAO Tian-yu1,HUA Yu-tao1,HE Rui1,LU Yan-kun2,TAN Hua-lu1,SONG Run-ze1,SHEN Jian-zhong1,**()
1 China National Center for Biotechnology Development, Beijing 100039, China
2 Hebei Science and Technology Innovation Service Center, Shijiazhuang 050021, China
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Abstract  

Human genetic resources refer to materials such as organs, tissues, cells and other materials that contain human genome, genes and other genetic materials, and the data they generate. Human genetic resources in China are extremely rich. It is significant for promoting life science, biomedicine and clinical research to utilize human genetic resources reasonably in China. In order to effectively protect, manage and utilize human genetic resources in China, the management department strictly follows the laws and regulations to execute administrative approval of human genetic resources. In this paper, the status of administrative license for collecting human genetic resources in 2021 in China is summarized. Then, the practical work is combined to analyze the existing problems. Finally, some recommendations are made for the management of human genetic resources in China.



Key wordsHuman      genetic      resources      Collection      Statistical      analysis     
Received: 22 March 2022      Published: 17 June 2022
ZTFLH:  Q38  
Corresponding Authors: Jian-zhong SHEN     E-mail: shenjz@cncbd.org.cn
Cite this article:

ZHAO Tian-yu,HUA Yu-tao,HE Rui,LU Yan-kun,TAN Hua-lu,SONG Run-ze,SHEN Jian-zhong. Status Analysis and Suggestions of Collecting Human Genetic Resources in China. China Biotechnology, 2022, 42(5): 139-145.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2203050     OR     https://manu60.magtech.com.cn/biotech/Y2022/V42/I5/139

采集首次项目类型 获批数量/项 所占比例/%
重要遗传家系人类遗传资源 46 1.95
特定地区人类遗传资源 156 6.62
科技部规定种类、数量的人类
遗传资源 2 155 91.43
Table 1 Summary of approved collection projects in 2021
序号 省份 获批数量/项 所占比例/%
1 北京 10 21.74
2 浙江 10 21.74
3 广东 5 10.87
4 湖南 4 8.70
5 上海 4 8.70
6 湖北 3 6.52
7 福建 2 4.35
8 陕西 2 4.35
9 重庆 2 4.35
10 内蒙古 1 2.17
11 广西 1 2.17
12 新疆 1 2.17
13 天津 1 2.17
Table 2 Distribution of human genetic resources collection projects for important genetic families approved in 2021
序号 申请单位 获批数量
/项
所占比例
/%
1 中国医学科学院北京协和医院 4 8.70
2 浙江大学医学院附属第二医院 4 8.70
3 浙江大学医学院附属妇产科医院 2 4.35
Table 3 Applicants of human genetic resources collection projects for important genetic families approved in 2021 (top three)
人类遗传资源用途 获批数量/项
利用 43
保藏 18
其他 1
Table 4 Classification of application in human genetic resources collection projects for important genetic families approved in 2021
人类遗传资源样本来源 获批数量/项
临床研究样本 43
保藏样本 9
其他 1
Table 5 Classification of sample sources in human genetic resources collection projects for important genetic families approved in 2021
序号 省份 获批数量/项 所占比例/%
1 青海 123 78.85
2 广东 11 7.05
3 北京 7 4.49
4 上海 4 2.57
5 浙江 3 1.92
6 四川 2 1.28
7 西藏 2 1.28
8 云南 2 1.28
9 湖南 1 0.64
10 湖北 1 0.64
Table 6 Distribution of human genetic resources collection projects for specific regions approved in 2021
序号 省份 获批单位/家 所占比例/%
1 青海 9 27.27
2 广东 6 18.18
3 北京 5 15.15
Table 7 Applicants of human genetic resources collection projects for specific regions approved in 2021 (top three)
序号 疾病类型 获批数量/项
1 肿瘤 39
2 内分泌、代谢及免疫系统 23
3 心血管 14
4 妇科 14
5 呼吸系统 13
6 神经系统 12
7 消化系统 12
8 五官 11
9 脑血管 10
10 环境与健康 10
11 感染性疾病 9
12 血液及造血系统 6
13 泌尿系统 5
14 精神系统 4
15 遗传性疾病 4
16 皮肤 3
17 儿科 1
18 其他 27
Table 8 Classification of disease involved in human genetic resources collection projects for specific regions approved in 2021
人类遗传资源用途 获批数量/项
利用 141
保藏 19
其他 11
Table 9 Classification of application in human genetic resources collection projects for specific regions approved in 2021
人类遗传资源样本来源 获批数量/项
临床研究样本 139
保藏样本 7
其他 15
Table 10 Classification of sample sources in human genetic resources collection projects for specific regions approved in 2021
序号 省份 获批数量/项 所占比例/%
1 北京 681 31.60
2 上海 332 15.41
3 广东 321 14.90
4 浙江 183 8.49
5 江苏 105 4.87
6 四川 61 2.83
7 湖北 59 2.74
8 天津 54 2.51
9 河南 53 2.46
10 重庆 44 2.04
Table 11 Distribution of human genetic resources collection projects for types and quantities specified by the Ministry of Science and Technology approved in 2021(top ten)
申请单位 获批数量
/项
所占比例
/%
1 中国医学科学院北京协和医院 99 4.59
2 北京大学人民医院 91 4.22
3 北京大学第一医院 67 3.11
Table 12 Applicants of human genetic resources collection projects for types and quantities specified by the Ministry of Science and Technology approved in 2021 (top three)
序号 疾病类型 获批数量/项
1 肿瘤 560
2 感染性疾病 380
3 内分泌、代谢及免疫系统 293
4 呼吸系统 270
5 其他 268
6 心血管 267
7 消化系统 206
8 神经系统 172
9 血液及造血系统 143
10 妇科 138
11 遗传性疾病 128
12 脑血管 128
13 儿科 114
14 泌尿系统 110
15 五官 68
16 皮肤 62
17 精神系统 52
18 环境与健康 52
Table 13 Classification of disease involved in human genetic resources collection projects for types and quantities specified by the Ministry of Science and Technology approved in 2021
人类遗传资源用途 获批数量/项
利用 2 052
保藏 147
其他 97
Table 14 Classification of application in human genetic resources collection projects for types and quantities specified by the Ministry of Science and Technology approved in 2021
人类遗传资源样本来源 获批数量/项
临床研究样本 1 714
保藏样本 42
其他 423
Table 15 Classification of sample sources in human genetic resources collection projects for types and quantities specified by the Ministry of Science and Technology approved in 2021
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