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| Progress in the Treatment of Inflammatory Bowel Diseases by Exosomes Derived from Mesenchymal Stem Cells |
LI Kai-xiu,SI Wei( ) |
| Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650504, China |
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Abstract Mesenchymal stem cells (MSC) play an important role in the treatment of inflammatory diseases through immune regulation and paracrine effect. The paracrine effect of MSC is mediated by secreting soble factors and releasing exosomes (Exo). Exosomes transfer DNA, proteins/peptides, mRNA, microRNA, lipids and organelles into recipient cells and display functions directly. Therefore, MSC-Exo instead of MSC provides a new strategy for the treatment of inflammatory bowel diseases. In this review, we summarize the progress of MSC-Exo derived from various tissues (bone marrow, umbilical cord and adipose) for the treatment of inflammatory bowel diseases.
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Received: 25 February 2021
Published: 03 August 2021
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Corresponding Authors:
Wei SI
E-mail: siw@lpbr.cn
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