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| Progress in Functions and Regulatory Mechanisms of the Transcription Factor Rex |
| MA Li, WU Hao, WANG Bin-bin, QIAO Jian-jun, ZHU Hong-ji |
| Key Laboratory of Systems Biotechnology of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China |
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Abstract Transcription factor Rex is a sensor of intracellular NADH/NAD+ redox state by incorporating either NADH or NAD+ in Gram-positive bacteria. In response to NADH/NAD+ ratio, Rex could control many physiological metabolisms by regulating genes expression. NAD[H], the key coenzyme in the metabolic network, could reflect the cellular redox state and influence the activity of Rex. The structures of Rex, either alone or bound with cofactor and/or DNA operator, have been determined in aerobic and anaerobic group. The regulatory mechanism of Rex and the relationship of Rex, NADH/NAD+, and target genes were revealed through comparative analysis on its structure in aerobic and anaerobic bacterial. Meanwhile, the connections of Rex with central carbon, energy metabolism, anaerobic metabolism, fermentation, biofilm formation, oxidative stress as well as cell toxicity were elucidated. In addition, further study trends and applications of Rex were discussed.
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Received: 28 March 2016
Published: 25 October 2016
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