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| The Progress of Study on Innate Immunity Led to the Design and Development of More Specific and Focused Adjuvants |
| SUN Ying-jun, ZHANG Yan, WU Qiong, ZHENG Hai-xue, ZHANG Zhi-dong |
| State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of the Ministry of Agriculture, National Foot-and-mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China |
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Abstract Recombinant DNA vaccines, subunit vaccines and synthetic peptide vaccines have sprung up one after another in recent years. These vaccines are characteristic with high purity, specificity, but they can not induce efficient immune response because of small molecule and low immunogenicity. Therefor, there is demand for safe and non-toxic adjuvants able to enhance the protective immune response. Recent advances in basic immunology have elucidated how early innate immune signals can shape subsequent adaptive responses, and this coupled with improvements in biochemical techniques, has led to the design and development of more specific and focused adjuvants.The type and mechanism of adjuvants, the progress of study on innate immunity and also explores future directions of adjuvant development are reviewed. All these could provide some references for the study on highly active, low toxicity adjuvants.
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Received: 11 November 2010
Published: 01 April 2011
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