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中国生物工程杂志

China Biotechnology
China Biotechnology  2020, Vol. 40 Issue (1-2): 57-64    DOI: 10.13523/j.cb.2002105
Orginal Article     
Patent Analysis of Global Coronavirus Vaccine
XIE Hua-ling,LV Lu-cheng,YANG Yan-ping()
National Science Library, Chinese Academy of Science, Beijing 100190, China
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Abstract  

Coronavirus is a kind of RNA virus which can infect human and animals. Coronavirus can cause severe diseases such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The coronavirus (SARS-CoV-2) is a new strain which has never been found in human body before. The rapid transmission of SARS-CoV-2 has aroused the attention of governments all over the world and actively sought for vaccines. This report based on the panoramic patent in the field of coronavirus vaccine, comprehensively analyzed the development trend of patents, the output of major countries and institutions. At the same time, the report focuses on revealing the development and distribution of human related vaccines, as well as the research and development status of human related vaccine products. The report aims to provide references and implications for scientific researchers and decision makers in the field of Coronavirus Vaccine.



Key wordsCoronavirus      SARS-CoV-2      COVID-19      Vaccine      Human related vaccines      Patent analysis     
Received: 09 February 2020      Published: 27 March 2020
ZTFLH:  Q819  
Corresponding Authors: Yan-ping YANG     E-mail: yangyp@mail.las.ac.cn
Cite this article:

XIE Hua-ling,LV Lu-cheng,YANG Yan-ping. Patent Analysis of Global Coronavirus Vaccine. China Biotechnology, 2020, 40(1-2): 57-64.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2002105     OR     https://manu60.magtech.com.cn/biotech/Y2020/V40/I1-2/57

Fig.1 Number of Patents Related to CoV Vaccines
Fig.2 Distribution of CoV Vaccine-Related Patents by Country/Region
Fig.3 Main International Organizations Applying for Patents Related to CoV Vaccines
Fig.4 Main Chinese Organizations Applying for Patents Related to CoV Vaccines
Fig.5 Distribution of CoV Vaccine-Related in Patents Focusing on Virus
序号 专利名称 专利申请机构 技术来
源国
专利家族布局
年份(优先权年)
类型
1 疫苗 葛兰素史克公司; 巴斯德研究所 英国 2008 人用
2 对抗布拉迪斯拉发钩端螺旋体和其他病原体的多价犬疫苗 辉瑞公司 美国 2004 兽用
3 对抗布拉迪斯拉发钩端螺旋体和其他病原体的多价犬疫苗 辉瑞公司 美国 2001 兽用
4 包含功能性缺失的基因组的冠状病毒样颗粒 乌得勒支大学; 科学技术基金会 荷兰 2003 人用
5 SARS相关联冠状病毒的新病毒株及其应用 巴斯德研究所; 国家科研中心; 巴黎第七大学 法国 2003 人用
6 用于治疗严重急性呼吸道综合征(SARS)的组合物和方法 惠氏控股有限公司 美国 2003 人用
7 由SARS相关联冠状病毒新病毒株的基因组编码的蛋白质和肽的用途 巴斯德研究所; 国家科研中心; 巴黎第七大学 法国 2003 人用
8 SARS病毒抗原的细胞表面表达载体和用该载体转化的微生物 生物领先公司; M D 实验室; 生物领先日本公司; 韩国生命工学研究院 韩国 2003 人用
Table 1 Quadrilateral Patents of CoV Vaccines
药物名称 针对疾病 研发机构 研发阶段
mRNA vaccine (2019 Chinese coronavirus infection) 2019 Chinese CoV
infection
ModeRNA Therapeutics Discovery
INO-4800 2019 Chinese CoV
infection
Inovio Pharmaceuticals Inc Discovery
GreMERSfi MERS Greffex Inc Discovery
MERS-CoV recombinant vaccine
(nanoparticle formulation)
MERS Novavax Inc No Development Reported
MERS-CoV vaccine MERS Baylor College of Medicine No Development Reported
MERS-rabies dual vaccine MERS Thomas Jefferson University No Development Reported
MERS Cov vaccine (recombinant viral
vector)
MERS The Jenner Institute Phase I Clinical
MVA-MERS-S MERS Ludwig-Maximilians University of Munich Phase I Clinical
BVRS-GamVac-Combi MERS Gamalei Institute of Epidemiology and Microbiology Phase II Clinical
INO-4700 MERS Inovio Pharmaceuticals Inc Phase II Clinical
ChAdOx1 MERS MERS Vaccitech Ltd./University of Oxford Phase I
GLS-5300 MERS Inovio Pharmaceuticals/GeneOne Life
Science
Phase I/II
Convalescent plasma MERS King Abdullah International Med Res Cent Phase II
MERS-CoV vaccine MERS National Institute of Allergy and Infectious Diseases Preclinical
MERS-Corona virus vaccine (recombinant live-attenuated measles virus vector) MERS Themis Bioscience GmbH Preclinical
MERS-Cov vaccine MERS Institute of Microbiology, CAS Preclinical
GREVAX/MERS MERS Greffex Preclinical
MVA-MERS-S DF1 MERS Universitaetsklinikum Hamburg- Eppendorf Preclinical
SARS vaccine (delipidated) SARS Lipid Sciences Inc Discontinued
SARS virus vaccine (adenoviral vector SARS GenPhar Inc Discontinued
VRC-SRSDNA015-00-VP SARS National Institutes of Health Discontinued
SARS vaccine (SimVec) SARS Genecure LLC Discovery
SARS vaccine SARS Protein Potential LLC Discovery
horse anti-SARS-CoV immunoglobulin SARS National Vaccine and Serum Institute No Development Reported
SARS coronavirus vaccine SARS Chiron Corp No Development Reported
adenovector-based vaccine (SARS
coronavirus)
SARS National Institute of Allergy and Infectious Diseases No Development Reported
spike and nucleocapsid protein-targeting
vaccine (SARS)
SARS Shanghai Genomics Inc No Development Reported
SARS-CoV recombinant vaccine
(nanoparticle)
SARS Novavax Inc No Development Reported
SARS vaccine SARS Crucell Switzerland AG No Development Reported
SARS vaccine (inactivated virus) SARS Sanofi Pasteur No Development Reported
RBD-S SARS vaccine (SARS) SARS Baylor College of Medicine No Development Reported
SARS vaccine (intramuscular SARS Shanghai TenGen Biomedical Co Ltd No Development Reported
SARS DNA vaccine (li protein
immunoregulating)
SARS Antigen Express Inc No Development Reported
influenza/SARS vaccine (deINS1 vector) SARS AVIR Green Hills Biotechnology AG No Development Reported
PVI-3000 SARS PeptiVir Inc No Development Reported
D-3252 SARS Protein Sciences Corp No Development Reported
universal influenza vaccine (influenza/
SARS/coronavirus infection)
SARS University of Colorado System Outlicensed
enveloped virus vaccine (influenza/
SARS/coronavirus infection)
SARS University of Colorado System Outlicensed
SARS vaccine (VEE vector) SARS AlphaVax Inc Preclinical
SARS coronavirus vaccine SARS Sinovac Biotech Ltd Suspended
recombinant coronavirus vaccine 其他 IBAkteriaSp z oo Discovery
MVA-S 其他 UniversitatAutonoma de Barcelona No Development Reported
Table 2 Research Development of CoV Vaccines
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[2]   ScienceDaily. Study: Pig virus is easily transmitted among chickens and turkeys.[2020-02-09]. https://www.sciencedaily.com/releases/2020/01/200115130430.htm.
[3]   CEPI. CEPI to fund three programmes to develop vaccines against the novel coronavirus, nCoV-2019.[2020-02-09]. https://cepi.net/news_cepi/cepi-to-fund-three-programmes-to-develop-vaccines-against-the-novel-coronavirus-ncov-2019/.
[4]   CNBC. Moderna working with the NIH on coronavirus vaccine.[2020-02-09]. https://www.cnbc.com/video/2020/01/27/moderna-working-with-the-nih-on-coronavirus-vaccine.html.
[5]   GSK. CEPI and GSK announce collaboration to strengthen the global effort to develop a vaccine for the 2019-nCoV virus. [2020-02-09]. https://www.gsk.com/en-gb/media/press-releases/cepi-and-gsk-announce-collaboration-to-strengthen-the-global-effort-to-develop-a-vaccine-for-the-2019-ncov-virus/.
[6]   Song Z, Xu Y, Bao L , et al. Pub crosstef From SARS to MERS, thrusting coronaviruses into the spotlight. Viruses, 2019,11(1):E59.
[7]   Zhang N, Tang J, Lu L , et al. Receptorbinding domain-based subunit vaccines against MERS-CoV. Virus Res, 2015,202:151.
[8]   Schindewolf C, Menachery V . Middle East respiratory syndrome vaccine candidates: Cautious optimism. Viruses, 2019,11(1):E74.
[9]   Cho H, Excler J L, Kim J H , et al. Development of Middle East respiratory syndrome coronavirus vaccines - Advances and challenges. Hum Vaccin Immunother, 2018,14(2):304.
[10]   Li F, Du L Y . MERS coronavirus: An emerging zoonotic virus. Viruses, 2019,11(7):E663.
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